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Chlorine in PDB 6s56: Crystal Structure of Human ATAD2 Bromodomain in Complex with N-(4- Chloro-3-(N,N-Dimethylsulfamoyl)Phenyl)-2-(2,5-Dioxo-3',4'-Dihydro- 2'H-Spiro[Imidazolidine-4,1'-Naphthalen]-1-Yl)AcetamideEnzymatic activity of Crystal Structure of Human ATAD2 Bromodomain in Complex with N-(4- Chloro-3-(N,N-Dimethylsulfamoyl)Phenyl)-2-(2,5-Dioxo-3',4'-Dihydro- 2'H-Spiro[Imidazolidine-4,1'-Naphthalen]-1-Yl)Acetamide
All present enzymatic activity of Crystal Structure of Human ATAD2 Bromodomain in Complex with N-(4- Chloro-3-(N,N-Dimethylsulfamoyl)Phenyl)-2-(2,5-Dioxo-3',4'-Dihydro- 2'H-Spiro[Imidazolidine-4,1'-Naphthalen]-1-Yl)Acetamide:
3.6.1.3; Protein crystallography data
The structure of Crystal Structure of Human ATAD2 Bromodomain in Complex with N-(4- Chloro-3-(N,N-Dimethylsulfamoyl)Phenyl)-2-(2,5-Dioxo-3',4'-Dihydro- 2'H-Spiro[Imidazolidine-4,1'-Naphthalen]-1-Yl)Acetamide, PDB code: 6s56
was solved by
C.Chung,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human ATAD2 Bromodomain in Complex with N-(4- Chloro-3-(N,N-Dimethylsulfamoyl)Phenyl)-2-(2,5-Dioxo-3',4'-Dihydro- 2'H-Spiro[Imidazolidine-4,1'-Naphthalen]-1-Yl)Acetamide
(pdb code 6s56). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human ATAD2 Bromodomain in Complex with N-(4- Chloro-3-(N,N-Dimethylsulfamoyl)Phenyl)-2-(2,5-Dioxo-3',4'-Dihydro- 2'H-Spiro[Imidazolidine-4,1'-Naphthalen]-1-Yl)Acetamide, PDB code: 6s56: Chlorine binding site 1 out of 1 in 6s56Go back to Chlorine Binding Sites List in 6s56
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human ATAD2 Bromodomain in Complex with N-(4- Chloro-3-(N,N-Dimethylsulfamoyl)Phenyl)-2-(2,5-Dioxo-3',4'-Dihydro- 2'H-Spiro[Imidazolidine-4,1'-Naphthalen]-1-Yl)Acetamide
Mono view Stereo pair view
Reference:
P.Bamborough,
C.W.Chung,
E.H.Demont,
A.M.Bridges,
P.D.Craggs,
D.P.Dixon,
P.Francis,
R.C.Furze,
P.Grandi,
E.J.Jones,
B.Karamshi,
K.Locke,
S.C.C.Lucas,
A.M.Michon,
D.J.Mitchell,
P.Pogany,
R.K.Prinjha,
C.Rau,
A.M.Roa,
A.D.Roberts,
R.J.Sheppard,
R.J.Watson.
A Qualified Success: Discovery of A New Series of ATAD2 Bromodomain Inhibitors with A Novel Binding Mode Using High-Throughput Screening and Hit Qualification. J.Med.Chem. V. 62 7506 2019.
Page generated: Sat Dec 12 13:38:37 2020
ISSN: ISSN 0022-2623 PubMed: 31398032 DOI: 10.1021/ACS.JMEDCHEM.9B00673 |
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