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Chlorine in PDB 6sgp: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu, PDB code: 6sgp was solved by C.Barinka, S.Shukla, L.Motlova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.90 / 1.58
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.349, 130.394, 158.538, 90.00, 90.00, 90.00
R / Rfree (%) 18 / 20.1

Other elements in 6sgp:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu also contains other interesting chemical elements:

Zinc (Zn) 2 atoms
Calcium (Ca) 1 atom
Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu (pdb code 6sgp). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu, PDB code: 6sgp:

Chlorine binding site 1 out of 1 in 6sgp

Go back to Chlorine Binding Sites List in 6sgp
Chlorine binding site 1 out of 1 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl822

b:24.5
occ:1.00
 O A:HOH946 3.2 23.3 1.0
ND2 A:ASN451 3.2 20.4 1.0
NE A:ARG534 3.4 26.7 1.0
N A:ASP453 3.4 20.3 1.0
NH2 A:ARG534 3.4 24.4 1.0
NH2 A:ARG536 3.4 31.7 1.0
CB A:ASP453 3.8 19.9 1.0
CZ A:ARG534 3.8 24.6 1.0
CB A:ARG534 3.9 21.9 1.0
NH2 A:ARG580 3.9 21.4 1.0
CA A:ASP453 3.9 21.1 1.0
CB A:ASN451 4.1 19.1 1.0
CG A:ASN451 4.1 19.8 1.0
C A:ASP453 4.2 22.8 1.0
CZ A:ARG536 4.2 35.1 1.0
N A:ALA452 4.2 20.3 1.0
O A:ASP453 4.3 22.3 1.0
C A:ASN451 4.3 21.1 1.0
C A:ALA452 4.4 20.7 1.0
CA A:ALA452 4.4 20.3 1.0
NE A:ARG536 4.4 32.1 1.0
CD A:ARG534 4.5 25.1 1.0
O A:ASN451 4.5 22.4 1.0
CG A:ARG534 4.6 23.6 1.0
O A:SER454 4.6 23.8 0.9
O A:SER454 4.7 23.1 0.1
CZ A:ARG580 4.8 22.3 1.0
N A:SER454 4.8 22.6 0.9
N A:SER454 4.9 22.3 0.1
O A:ALA535 4.9 21.6 1.0
CA A:ARG534 4.9 21.0 1.0
CA A:ASN451 4.9 19.2 1.0
N A:ALA535 5.0 21.2 1.0

Reference:

C.Barinka, S.Shukla, L.Motlova. X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu To Be Published.
Page generated: Mon Jul 29 14:57:54 2024

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