Chlorine in PDB 6sqp: Crystal Structure of Cat MDM2-S429E Ring Domain Homodimer

All present enzymatic activity of Crystal Structure of Cat MDM2-S429E Ring Domain Homodimer:
2.3.2.27;

The structure of Crystal Structure of Cat MDM2-S429E Ring Domain Homodimer, PDB code: 6sqp was solved by H.M.Magnussen, S.F.Ahmed, D.T.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.53 / 1.21
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	29.240, 39.760, 104.380, 90.00, 93.40, 90.00
R / Rfree (%)	17.1 / 21.2

The structure of Crystal Structure of Cat MDM2-S429E Ring Domain Homodimer also contains other interesting chemical elements:

Zinc

(Zn)

8 atoms

The binding sites of Chlorine atom in the Crystal Structure of Cat MDM2-S429E Ring Domain Homodimer (pdb code 6sqp). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Cat MDM2-S429E Ring Domain Homodimer, PDB code: 6sqp:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Cat MDM2-S429E Ring Domain Homodimer


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Cat MDM2-S429E Ring Domain Homodimer within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl503 b:15.7 occ:1.00 O A:HOH622 3.2 19.8 1.0 NH2 A:ARG479 3.3 11.9 1.0 NH1 A:ARG479 3.4 12.8 1.0 CD A:PRO474 3.8 12.7 1.0 CZ A:ARG479 3.8 13.5 1.0 CG A:PRO474 4.1 13.6 1.0 CD A:LYS473 4.1 30.4 1.0 CE A:LYS473 4.3 32.7 1.0 CB A:LYS473 4.5 19.0 1.0 NZ A:LYS473 4.8 34.0 1.0 N A:PRO474 4.8 12.3 1.0 CG A:LYS473 4.9 25.8 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Cat MDM2-S429E Ring Domain Homodimer


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Cat MDM2-S429E Ring Domain Homodimer within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl503 b:13.9 occ:1.00 O C:HOH655 3.2 12.9 1.0 O D:HOH630 3.2 26.8 1.0 O C:HOH661 3.4 37.5 1.0 CD2 C:TYR489 4.0 10.2 1.0 CE2 C:TYR489 4.1 11.6 1.0 O C:HOH653 4.7 24.5 1.0 CB D:GLU427 4.8 16.4 1.0 O D:HOH628 4.9 20.9 1.0 O C:HOH604 5.0 19.8 1.0 O C:HOH629 5.0 10.7 1.0

H.M.Magnussen, S.F.Ahmed, G.J.Sibbet, V.A.Hristova, K.Nomura, A.K.Hock, L.J.Archibald, A.G.Jamieson, D.Fushman, K.H.Vousden, A.M.Weissman, D.T.Huang. Structural Basis For Dna Damage-Induced Phosphoregulation of MDM2 Ring Domain Nat Commun 2020.
ISSN: ESSN 2041-1723