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Chlorine in PDB 6t5v: KRASG12C Ligand ComplexProtein crystallography data
The structure of KRASG12C Ligand Complex, PDB code: 6t5v
was solved by
C.Phillips,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6t5v:
The structure of KRASG12C Ligand Complex also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the KRASG12C Ligand Complex
(pdb code 6t5v). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the KRASG12C Ligand Complex, PDB code: 6t5v: Chlorine binding site 1 out of 1 in 6t5vGo back to Chlorine Binding Sites List in 6t5v
Chlorine binding site 1 out
of 1 in the KRASG12C Ligand Complex
Mono view Stereo pair view
Reference:
J.G.Kettle,
S.Bagal,
S.Bickerton,
M.S.Bodnarchuk,
J.Breed,
R.J.Carbajo,
D.Cassar,
A.Chakraborty,
S.Cosulich,
I.Cumming,
M.Davies,
A.Eatherton,
L.Evans,
L.J.Feron,
S.M.Fillery,
E.S.Gleave,
F.W.Goldberg,
S.Harlfinger,
L.Hanson,
M.Howard,
R.Howells,
A.Jackson,
P.D.Kemmitt,
J.Kingston,
S.Lamont,
H.Lewis,
S.Li,
L.Liu,
D.Ogg,
C.Phillips,
R.Polanski,
G.R.Robb,
D.Robinson,
S.Ross,
J.Smith,
M.Tonge,
R.Whiteley,
J.Yang,
L.Zhang,
X.Zhao.
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant Gtpase KRASG12C. J.Med.Chem. 2020.
Page generated: Sat Dec 12 13:43:07 2020
ISSN: ISSN 0022-2623 PubMed: 32023060 DOI: 10.1021/ACS.JMEDCHEM.9B01720 |
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