Chlorine in PDB 6t8m: Prolyl Hydroxylase (Phd) Involved in Hypoxia Sensing By Dictyostelium Discoideum

The structure of Prolyl Hydroxylase (Phd) Involved in Hypoxia Sensing By Dictyostelium Discoideum, PDB code: 6t8m was solved by R.Chowdhury, M.A.Mcdonough, T.Liu, I.J.Clifton, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.92 / 2.02
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	45.216, 81.781, 379.210, 90.00, 90.00, 90.00
R / Rfree (%)	22.8 / 25.7

The structure of Prolyl Hydroxylase (Phd) Involved in Hypoxia Sensing By Dictyostelium Discoideum also contains other interesting chemical elements:

Nickel

(Ni)

5 atoms

The binding sites of Chlorine atom in the Prolyl Hydroxylase (Phd) Involved in Hypoxia Sensing By Dictyostelium Discoideum (pdb code 6t8m). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Prolyl Hydroxylase (Phd) Involved in Hypoxia Sensing By Dictyostelium Discoideum, PDB code: 6t8m:

Chlorine binding site 1 out of 1 in the Prolyl Hydroxylase (Phd) Involved in Hypoxia Sensing By Dictyostelium Discoideum


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Prolyl Hydroxylase (Phd) Involved in Hypoxia Sensing By Dictyostelium Discoideum within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl304 b:80.7 occ:1.00 NZ C:LYS160 3.6 61.1 1.0 OG C:SER172 3.9 66.3 1.0 O C:ILE173 4.1 62.3 1.0 CE C:LYS160 4.2 61.0 1.0 O C:SER172 4.3 67.1 1.0 C C:ILE173 4.7 62.2 1.0 CD C:LYS160 4.7 59.1 1.0

T.Liu, M.I.Abboud, R.Chowdhury, A.Tumber, A.P.Hardy, K.Lippl, C.T.Lohans, E.Pires, J.Wickens, M.A.Mcdonough, C.M.West, C.J.Schofield. Biochemical and Biophysical Analyses of Hypoxia Sensing Prolyl Hydroxylases From Dictyostelium Discoideum and Toxoplasma Gondii. J.Biol.Chem. 2020.
ISSN: ESSN 1083-351X
PubMed: 32934009
DOI: 10.1074/JBC.RA120.013998