Chlorine in PDB 6tlk: Structure of Methylene-Tetrahydromethanopterin Dehydrogenase From Methylorubrum Extorquens AM1 in An Open Conformation Containing Nadp+ and Methylene-H4MPT

Enzymatic activity of Structure of Methylene-Tetrahydromethanopterin Dehydrogenase From Methylorubrum Extorquens AM1 in An Open Conformation Containing Nadp+ and Methylene-H4MPT

All present enzymatic activity of Structure of Methylene-Tetrahydromethanopterin Dehydrogenase From Methylorubrum Extorquens AM1 in An Open Conformation Containing Nadp+ and Methylene-H4MPT:
1.5.1.5;

Protein crystallography data

The structure of Structure of Methylene-Tetrahydromethanopterin Dehydrogenase From Methylorubrum Extorquens AM1 in An Open Conformation Containing Nadp+ and Methylene-H4MPT, PDB code: 6tlk was solved by T.Wagner, G.Huang, U.Demmer, E.Warkentin, U.Ermler, S.Shima, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 26.35 / 1.80
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 76.923, 149.267, 78.559, 90.00, 93.64, 90.00
R / Rfree (%) 16.6 / 20.1

Other elements in 6tlk:

The structure of Structure of Methylene-Tetrahydromethanopterin Dehydrogenase From Methylorubrum Extorquens AM1 in An Open Conformation Containing Nadp+ and Methylene-H4MPT also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Methylene-Tetrahydromethanopterin Dehydrogenase From Methylorubrum Extorquens AM1 in An Open Conformation Containing Nadp+ and Methylene-H4MPT (pdb code 6tlk). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Methylene-Tetrahydromethanopterin Dehydrogenase From Methylorubrum Extorquens AM1 in An Open Conformation Containing Nadp+ and Methylene-H4MPT, PDB code: 6tlk:

Chlorine binding site 1 out of 1 in 6tlk

Go back to Chlorine Binding Sites List in 6tlk
Chlorine binding site 1 out of 1 in the Structure of Methylene-Tetrahydromethanopterin Dehydrogenase From Methylorubrum Extorquens AM1 in An Open Conformation Containing Nadp+ and Methylene-H4MPT


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Methylene-Tetrahydromethanopterin Dehydrogenase From Methylorubrum Extorquens AM1 in An Open Conformation Containing Nadp+ and Methylene-H4MPT within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl403

b:57.3
occ:1.00
O D:HOH526 2.6 52.6 1.0
O F:HOH688 2.7 50.9 1.0
ND1 D:HIS30 2.7 23.5 1.0
ND1 E:HIS30 2.7 25.7 1.0
ND1 F:HIS30 3.2 24.6 1.0
CE1 D:HIS30 3.5 24.2 1.0
CE1 E:HIS30 3.5 27.5 1.0
OH E:TYR24 3.6 22.2 1.0
CE1 F:HIS30 3.7 25.3 1.0
CG E:HIS30 3.9 25.9 1.0
CG D:HIS30 3.9 21.2 1.0
OH D:TYR24 4.0 20.4 1.0
OH F:TYR24 4.1 17.5 1.0
CB E:HIS30 4.2 22.6 1.0
O E:HOH549 4.2 31.3 1.0
CA E:HIS30 4.2 23.1 1.0
O E:ASP29 4.2 25.0 1.0
CB D:HIS30 4.3 17.1 1.0
CG F:HIS30 4.4 22.5 1.0
CA D:HIS30 4.4 18.3 1.0
O D:ASP29 4.6 20.6 1.0
O D:HOH515 4.6 33.5 1.0
O F:HOH529 4.6 32.0 1.0
CZ E:TYR24 4.6 25.2 1.0
NE2 D:HIS30 4.7 24.0 1.0
NE2 E:HIS30 4.8 27.2 1.0
CE1 E:TYR24 4.9 22.5 1.0
CB F:HIS30 4.9 17.4 1.0
N E:ILE31 4.9 19.2 1.0
CD2 D:HIS30 4.9 24.4 1.0
CD2 E:HIS30 4.9 25.2 1.0
O F:ASP29 5.0 20.3 1.0
CA F:HIS30 5.0 17.5 1.0

Reference:

G.Huang, T.Wagner, U.Demmer, E.Warkentin, U.Ermler, S.Shima. The Hydride Transfer Process in Nadp Dependent Methylene-Tetrahydromethanopterin Dehydrogenase. J.Mol.Biol. 2020.
ISSN: ESSN 1089-8638
PubMed: 32061937
DOI: 10.1016/J.JMB.2020.01.042
Page generated: Sat Dec 12 13:44:51 2020

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