Chlorine in PDB 6tlr: Human CK2 Kinase Alpha Subunit in Complex with the Atp-Competitive Inhibitor 4,7-Dibromobenzotriazole

Enzymatic activity of Human CK2 Kinase Alpha Subunit in Complex with the Atp-Competitive Inhibitor 4,7-Dibromobenzotriazole

All present enzymatic activity of Human CK2 Kinase Alpha Subunit in Complex with the Atp-Competitive Inhibitor 4,7-Dibromobenzotriazole:
2.7.11.1;

Protein crystallography data

The structure of Human CK2 Kinase Alpha Subunit in Complex with the Atp-Competitive Inhibitor 4,7-Dibromobenzotriazole, PDB code: 6tlr was solved by H.Czapinska, A.Piasecka, M.Winiewska-Szajewska, M.Bochtler, J.Poznanski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.28 / 1.64
Space group P 42 21 2
Cell size a, b, c (Å), α, β, γ (°) 128.326, 128.326, 61.192, 90.00, 90.00, 90.00
R / Rfree (%) 14.9 / 17.8

Other elements in 6tlr:

The structure of Human CK2 Kinase Alpha Subunit in Complex with the Atp-Competitive Inhibitor 4,7-Dibromobenzotriazole also contains other interesting chemical elements:

Bromine (Br) 6 atoms
Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human CK2 Kinase Alpha Subunit in Complex with the Atp-Competitive Inhibitor 4,7-Dibromobenzotriazole (pdb code 6tlr). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human CK2 Kinase Alpha Subunit in Complex with the Atp-Competitive Inhibitor 4,7-Dibromobenzotriazole, PDB code: 6tlr:

Chlorine binding site 1 out of 1 in 6tlr

Go back to Chlorine Binding Sites List in 6tlr
Chlorine binding site 1 out of 1 in the Human CK2 Kinase Alpha Subunit in Complex with the Atp-Competitive Inhibitor 4,7-Dibromobenzotriazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human CK2 Kinase Alpha Subunit in Complex with the Atp-Competitive Inhibitor 4,7-Dibromobenzotriazole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl404

b:39.0
occ:1.00
 N A:HIS160 3.3 28.5 0.3
N A:HIS160 3.3 29.3 0.7
ND1 A:HIS160 3.3 33.6 0.3
CB A:HIS160 3.4 30.2 0.3
CD A:PRO159 3.5 27.9 1.0
CB A:HIS160 3.6 33.4 0.7
N A:PRO159 3.8 26.4 1.0
CG A:HIS160 3.8 32.2 0.3
CD A:LYS158 3.8 31.4 1.0
CB A:LYS158 3.9 26.9 1.0
CG A:LYS158 3.9 28.3 1.0
CD A:LYS122 3.9 49.5 1.0
O A:HOH981 3.9 57.2 1.0
CA A:HIS160 4.0 28.6 0.3
CB A:PRO159 4.0 28.5 1.0
CA A:HIS160 4.0 30.1 0.7
CG A:PRO159 4.1 29.5 1.0
C A:PRO159 4.2 28.0 1.0
CA A:PRO159 4.2 28.2 1.0
C A:LYS158 4.4 25.9 1.0
CE2 A:PHE197 4.5 26.0 1.0
NZ A:LYS122 4.5 55.3 1.0
CE1 A:HIS160 4.5 33.7 0.3
CG A:LYS122 4.6 46.5 1.0
CE A:LYS158 4.6 34.2 1.0
CE A:LYS122 4.7 53.7 1.0
CA A:LYS158 4.7 25.8 1.0
CZ A:PHE197 4.8 27.1 1.0
CB A:LYS122 4.9 43.4 1.0
CG A:HIS160 4.9 37.4 0.7
O A:HOH890 5.0 43.8 1.0

Reference:

H.Czapinska, A.Piasecka, M.Winiewska-Szajewska, M.Bochtler, J.Poznanski. Binding of Bromobenzotriazoles By the Catalytic Subunit of Human Protein Kinase CK2: Structural and Thermodynamics Studies. To Be Published.
Page generated: Thu Dec 17 10:45:41 2020

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