Chlorine in PDB 6txb: Crystal Structure of MINDY1 Mutant (P138A) in Complex with LYS48 Linked Di-Ubiquitin

All present enzymatic activity of Crystal Structure of MINDY1 Mutant (P138A) in Complex with LYS48 Linked Di-Ubiquitin:
3.4.19.12;

The structure of Crystal Structure of MINDY1 Mutant (P138A) in Complex with LYS48 Linked Di-Ubiquitin, PDB code: 6txb was solved by S.A.Abdul Rehman, Y.Kulathu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.84 / 2.18
Space group	P 41 2 2
Cell size a, b, c (Å), α, β, γ (°)	74.032, 74.032, 202.853, 90, 90, 90
R / Rfree (%)	21.3 / 24.7

The structure of Crystal Structure of MINDY1 Mutant (P138A) in Complex with LYS48 Linked Di-Ubiquitin also contains other interesting chemical elements:

Sodium

(Na)

4 atoms

The binding sites of Chlorine atom in the Crystal Structure of MINDY1 Mutant (P138A) in Complex with LYS48 Linked Di-Ubiquitin (pdb code 6txb). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of MINDY1 Mutant (P138A) in Complex with LYS48 Linked Di-Ubiquitin, PDB code: 6txb:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of MINDY1 Mutant (P138A) in Complex with LYS48 Linked Di-Ubiquitin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of MINDY1 Mutant (P138A) in Complex with LYS48 Linked Di-Ubiquitin within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl404 b:90.1 occ:1.00 N A:GLU159 3.5 61.2 1.0 N A:VAL160 3.9 59.5 1.0 CG A:LYS158 4.1 63.7 1.0 CA A:LYS158 4.1 65.3 1.0 O A:VAL160 4.1 60.7 1.0 C A:LYS158 4.3 60.5 1.0 CA A:GLU159 4.4 61.3 1.0 CB A:GLU159 4.4 65.2 1.0 C A:GLU159 4.7 58.7 1.0 CB A:LYS158 4.7 63.3 1.0 CA A:VAL160 4.7 60.5 1.0 CB A:VAL160 4.8 64.2 1.0 C A:VAL160 4.9 59.5 1.0 NZ A:LYS158 5.0 66.2 1.0 O A:GLN157 5.0 78.8 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of MINDY1 Mutant (P138A) in Complex with LYS48 Linked Di-Ubiquitin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of MINDY1 Mutant (P138A) in Complex with LYS48 Linked Di-Ubiquitin within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl405 b:79.0 occ:1.00 N A:GLU308 3.6 53.3 1.0 CB A:GLU308 4.1 58.0 1.0 CA A:LYS307 4.1 55.3 1.0 NZ A:LYS325 4.2 52.4 1.0 O A:ALA306 4.2 50.4 1.0 CD A:LYS307 4.4 75.8 1.0 C A:LYS307 4.4 52.4 1.0 CA A:GLU308 4.5 53.7 1.0 CE A:LYS325 4.7 51.7 1.0 CB A:LYS307 4.9 60.9 1.0 CD A:LYS325 4.9 50.4 1.0

S.A.Abdul Rehman, Y.Kulathu. Structural Basis For the Activation and Regulation of Deubiquitinase Activity in MINDY1 and MINDY2 To Be Published.