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Chlorine in PDB 6u7p: Hiv-1 Wild Type Protease with Grl-03119A, with Phenyl-Boronic-Acid As P2'-Ligand and with A Hexahydro-4H-Furo-Pyran As the P2-LigandProtein crystallography data
The structure of Hiv-1 Wild Type Protease with Grl-03119A, with Phenyl-Boronic-Acid As P2'-Ligand and with A Hexahydro-4H-Furo-Pyran As the P2-Ligand, PDB code: 6u7p
was solved by
Y.-F.Wang,
D.W.Kneller,
I.T.Weber,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6u7p:
The structure of Hiv-1 Wild Type Protease with Grl-03119A, with Phenyl-Boronic-Acid As P2'-Ligand and with A Hexahydro-4H-Furo-Pyran As the P2-Ligand also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Hiv-1 Wild Type Protease with Grl-03119A, with Phenyl-Boronic-Acid As P2'-Ligand and with A Hexahydro-4H-Furo-Pyran As the P2-Ligand
(pdb code 6u7p). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Hiv-1 Wild Type Protease with Grl-03119A, with Phenyl-Boronic-Acid As P2'-Ligand and with A Hexahydro-4H-Furo-Pyran As the P2-Ligand, PDB code: 6u7p: Jump to Chlorine binding site number: 1; 2; 3; 4; 5; Chlorine binding site 1 out of 5 in 6u7pGo back to![]() ![]()
Chlorine binding site 1 out
of 5 in the Hiv-1 Wild Type Protease with Grl-03119A, with Phenyl-Boronic-Acid As P2'-Ligand and with A Hexahydro-4H-Furo-Pyran As the P2-Ligand
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 5 in 6u7pGo back to![]() ![]()
Chlorine binding site 2 out
of 5 in the Hiv-1 Wild Type Protease with Grl-03119A, with Phenyl-Boronic-Acid As P2'-Ligand and with A Hexahydro-4H-Furo-Pyran As the P2-Ligand
![]() Mono view ![]() Stereo pair view
Chlorine binding site 3 out of 5 in 6u7pGo back to![]() ![]()
Chlorine binding site 3 out
of 5 in the Hiv-1 Wild Type Protease with Grl-03119A, with Phenyl-Boronic-Acid As P2'-Ligand and with A Hexahydro-4H-Furo-Pyran As the P2-Ligand
![]() Mono view ![]() Stereo pair view
Chlorine binding site 4 out of 5 in 6u7pGo back to![]() ![]()
Chlorine binding site 4 out
of 5 in the Hiv-1 Wild Type Protease with Grl-03119A, with Phenyl-Boronic-Acid As P2'-Ligand and with A Hexahydro-4H-Furo-Pyran As the P2-Ligand
![]() Mono view ![]() Stereo pair view
Chlorine binding site 5 out of 5 in 6u7pGo back to![]() ![]()
Chlorine binding site 5 out
of 5 in the Hiv-1 Wild Type Protease with Grl-03119A, with Phenyl-Boronic-Acid As P2'-Ligand and with A Hexahydro-4H-Furo-Pyran As the P2-Ligand
![]() Mono view ![]() Stereo pair view
Reference:
A.K.Ghosh,
Z.Xia,
S.Kovela,
W.L.Robinson,
M.E.Johnson,
D.W.Kneller,
Y.F.Wang,
M.Aoki,
Y.Takamatsu,
I.T.Weber,
H.Mitsuya.
Potent Hiv-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-Ray Structural Studies. Chemmedchem V. 14 1863 2019.
Page generated: Sat Dec 12 13:49:48 2020
ISSN: ESSN 1860-7187 PubMed: 31549492 DOI: 10.1002/CMDC.201900508 |
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