Chlorine in PDB 6ubw: Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody

Enzymatic activity of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody

All present enzymatic activity of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody:
2.7.10.1;

Protein crystallography data

The structure of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody, PDB code: 6ubw was solved by I.D.Hoffman, J.D.Lawson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 42.414, 47.398, 160.607, 90.00, 90.00, 90.00
R / Rfree (%) 18.7 / 22.5

Other elements in 6ubw:

The structure of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody also contains other interesting chemical elements:

Fluorine (F) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody (pdb code 6ubw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody, PDB code: 6ubw:

Chlorine binding site 1 out of 1 in 6ubw

Go back to Chlorine Binding Sites List in 6ubw
Chlorine binding site 1 out of 1 in the Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1402

b:26.5
occ:1.00
 O A:HOH1565 3.1 26.4 1.0
N A:HIS1348 3.3 34.5 1.0
N A:GLY1346 3.3 32.4 1.0
N A:GLU1347 3.3 36.4 1.0
CA A:GLY1346 3.3 33.5 1.0
N A:LYS1179 3.4 22.4 1.0
C A:GLY1346 3.6 35.0 1.0
N A:VAL1178 3.8 21.9 1.0
CB A:HIS1348 3.8 34.1 1.0
CB A:LYS1179 3.8 24.5 1.0
CB A:VAL1178 3.8 22.4 1.0
CD2 A:PHE1344 3.9 24.2 1.0
O A:HIS1348 3.9 28.2 1.0
CB A:THR1177 4.0 24.4 1.0
CB A:PHE1344 4.0 23.8 1.0
CA A:HIS1348 4.0 33.5 1.0
CA A:VAL1178 4.2 21.6 1.0
CD2 A:HIS1348 4.2 38.6 1.0
CA A:LYS1179 4.2 23.1 1.0
C A:GLU1347 4.3 37.0 1.0
C A:VAL1178 4.3 21.5 1.0
OG1 A:THR1177 4.3 23.2 1.0
CA A:GLU1347 4.3 39.3 1.0
CG A:PHE1344 4.3 23.7 1.0
CG A:HIS1348 4.4 37.1 1.0
C A:HIS1348 4.4 31.6 1.0
N A:ILE1345 4.4 29.9 1.0
C A:ILE1345 4.5 33.3 1.0
O A:GLY1346 4.6 36.0 1.0
C A:THR1177 4.6 22.0 1.0
CG2 A:VAL1178 4.7 22.6 1.0
CG1 A:VAL1178 4.8 21.5 1.0
CG2 A:THR1177 4.8 26.2 1.0
CA A:THR1177 4.8 23.5 1.0
CA A:PHE1344 4.9 25.9 1.0
CE2 A:PHE1344 4.9 24.1 1.0
C A:PHE1344 4.9 28.0 1.0

Reference:

P.J.Farrell, J.Matuszkiewicz, D.Balakrishna, S.Pandya, M.S.Hixon, R.Kamran, S.Chu, J.D.Lawson, K.Okada, A.Hori, A.Mizutani, H.Iwata, R.De Jong, B.Hibner, P.Vincent. Met Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of An Hgf Antibody. Mol. Cancer Ther. 2017.
ISSN: ESSN 1538-8514
PubMed: 28341789
DOI: 10.1158/1535-7163.MCT-16-0771
Page generated: Sat Dec 12 13:58:38 2020

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