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Atomistry » Chlorine » PDB 6udv-6ur3 » 6ufd » |
Chlorine in PDB 6ufd: Carbonic Anhydrase 2 with Inhibitor (2Z)-3-Oxo-N-(4-Sulfamoylphenyl)- 2-[(Thiophen-2-Yl)Methylidene]Butanamide (11G/D7)Enzymatic activity of Carbonic Anhydrase 2 with Inhibitor (2Z)-3-Oxo-N-(4-Sulfamoylphenyl)- 2-[(Thiophen-2-Yl)Methylidene]Butanamide (11G/D7)
All present enzymatic activity of Carbonic Anhydrase 2 with Inhibitor (2Z)-3-Oxo-N-(4-Sulfamoylphenyl)- 2-[(Thiophen-2-Yl)Methylidene]Butanamide (11G/D7):
4.2.1.1; Protein crystallography data
The structure of Carbonic Anhydrase 2 with Inhibitor (2Z)-3-Oxo-N-(4-Sulfamoylphenyl)- 2-[(Thiophen-2-Yl)Methylidene]Butanamide (11G/D7), PDB code: 6ufd
was solved by
T.S.Peat,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6ufd:
The structure of Carbonic Anhydrase 2 with Inhibitor (2Z)-3-Oxo-N-(4-Sulfamoylphenyl)- 2-[(Thiophen-2-Yl)Methylidene]Butanamide (11G/D7) also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Carbonic Anhydrase 2 with Inhibitor (2Z)-3-Oxo-N-(4-Sulfamoylphenyl)- 2-[(Thiophen-2-Yl)Methylidene]Butanamide (11G/D7)
(pdb code 6ufd). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Carbonic Anhydrase 2 with Inhibitor (2Z)-3-Oxo-N-(4-Sulfamoylphenyl)- 2-[(Thiophen-2-Yl)Methylidene]Butanamide (11G/D7), PDB code: 6ufd: Chlorine binding site 1 out of 1 in 6ufdGo back to![]() ![]()
Chlorine binding site 1 out
of 1 in the Carbonic Anhydrase 2 with Inhibitor (2Z)-3-Oxo-N-(4-Sulfamoylphenyl)- 2-[(Thiophen-2-Yl)Methylidene]Butanamide (11G/D7)
![]() Mono view ![]() Stereo pair view
Reference:
M.Fares,
W.M.Eldehna,
S.Bua,
C.Lanzi,
L.Lucarini,
E.Masini,
T.S.Peat,
H.A.Abdel-Aziz,
A.Nocentini,
P.A.Keller,
C.T.Supuran.
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action. J.Med.Chem. V. 63 3317 2020.
Page generated: Sat Jul 12 20:31:56 2025
ISSN: ISSN 0022-2623 PubMed: 32031797 DOI: 10.1021/ACS.JMEDCHEM.9B02090 |
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