Chlorine in PDB 6umw: Crystal Structure of HEPHB1 Bound with Chlortetracycline

All present enzymatic activity of Crystal Structure of HEPHB1 Bound with Chlortetracycline:
2.7.10.1;

The structure of Crystal Structure of HEPHB1 Bound with Chlortetracycline, PDB code: 6umw was solved by M.Ahmed, P.Wang, H.Sadek, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.23 / 1.98
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	32.932, 91.090, 96.995, 90.00, 90.00, 90.00
R / Rfree (%)	18.2 / 22.1

The binding sites of Chlorine atom in the Crystal Structure of HEPHB1 Bound with Chlortetracycline (pdb code 6umw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of HEPHB1 Bound with Chlortetracycline, PDB code: 6umw:

Chlorine binding site 1 out of 1 in the Crystal Structure of HEPHB1 Bound with Chlortetracycline


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of HEPHB1 Bound with Chlortetracycline within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl901 b:51.2 occ:0.58 CL7 A:CTC901 0.0 51.2 0.6 C7 A:CTC901 1.7 28.1 0.6 C8 A:CTC901 2.7 30.8 0.6 C6A A:CTC901 2.7 25.2 0.6 O A:HOH1092 2.7 29.0 1.0 C6' A:CTC901 2.9 34.0 0.6 C6 A:CTC901 3.1 31.5 0.6 O6 A:CTC901 3.1 36.8 0.6 O A:ILE625 3.8 32.6 1.0 C9 A:CTC901 4.0 30.2 0.6 C6B A:CTC901 4.0 28.7 0.6 O A:HOH1133 4.4 40.0 1.0 C10 A:CTC901 4.5 26.0 0.6 N A:ALA704 4.5 12.8 1.0 C5A A:CTC901 4.6 30.4 0.6 CD2 A:LEU751 4.6 22.8 1.0 CB A:ALA704 4.9 16.2 1.0 CA A:GLY703 4.9 12.0 1.0

M.Ahmed, P.Wang, Y.Nakada, I.Menendez-Montes, M.Ismail, M.Henkemeyer, H.Sadek, E.Kandil. Identification of Tetracycline Combinations As Ephb Tyrosine Kinase Inhibitors For Treatment of Neuropathic Pain To Be Published.