Chlorine in PDB 6v0q: Crystal Structure of the Bromodomain of Human BRD7 Bound to TG003

The structure of Crystal Structure of the Bromodomain of Human BRD7 Bound to TG003, PDB code: 6v0q was solved by M.R.Karim, A.Chan, E.Schonbrunn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.68 / 1.69
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	59.970, 36.780, 118.960, 90.00, 101.77, 90.00
R / Rfree (%)	18.1 / 21.8

The binding sites of Chlorine atom in the Crystal Structure of the Bromodomain of Human BRD7 Bound to TG003 (pdb code 6v0q). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Bromodomain of Human BRD7 Bound to TG003, PDB code: 6v0q:

Chlorine binding site 1 out of 1 in the Crystal Structure of the Bromodomain of Human BRD7 Bound to TG003


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Bromodomain of Human BRD7 Bound to TG003 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl304 b:50.8 occ:1.00 O A:HOH442 3.4 29.9 1.0 N A:GLN234 3.4 17.7 1.0 O A:HOH486 3.6 34.7 1.0 CB A:GLN234 3.9 21.8 1.0 CA A:SER233 4.1 18.6 1.0 C A:SER233 4.3 20.7 1.0 CA A:GLN234 4.3 19.3 1.0 CB A:SER233 4.3 21.2 1.0 NZ A:LYS197 4.7 24.7 1.0 O A:HOH520 4.9 25.9 1.0

R.M.Karim, A.Chan, J.Y.Zhu, E.Schonbrunn. Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J.Med.Chem. 2020.
ISSN: ISSN 0022-2623
PubMed: 32091206
DOI: 10.1021/ACS.JMEDCHEM.9B01980