Chlorine »
PDB 6uqv-6v4m »
6v2f »
Chlorine in PDB 6v2f: Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207
Protein crystallography data
The structure of Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207, PDB code: 6v2f
was solved by
T.C.Appleby,
J.O.Link,
S.R.Yant,
A.G.Villasenor,
J.R.Somoza,
E.Y.Hu,
S.D.Schroeder,
T.Cihlar,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.92 / 2.00 |
| Space group | P 3 |
| Cell size a, b, c (Å), α, β, γ (°) | 158.301, 158.301, 55.648, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 20.9 / 25.1 |
Other elements in 6v2f:
The structure of Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207 also contains other interesting chemical elements:
| Fluorine | (F) | 60 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207
(pdb code 6v2f). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207, PDB code: 6v2f:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Chlorine where determined in the Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207, PDB code: 6v2f:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;
Chlorine binding site 1 out of 6 in 6v2f
Go back to
Chlorine Binding Sites List in 6v2f
Chlorine binding site 1 out
of 6 in the Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207 within 5.0Å range:
|
Chlorine binding site 2 out of 6 in 6v2f
Go back to
Chlorine Binding Sites List in 6v2f
Chlorine binding site 2 out
of 6 in the Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207 within 5.0Å range:
|
Chlorine binding site 3 out of 6 in 6v2f
Go back to
Chlorine Binding Sites List in 6v2f
Chlorine binding site 3 out
of 6 in the Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207 within 5.0Å range:
|
Chlorine binding site 4 out of 6 in 6v2f
Go back to
Chlorine Binding Sites List in 6v2f
Chlorine binding site 4 out
of 6 in the Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207 within 5.0Å range:
|
Chlorine binding site 5 out of 6 in 6v2f
Go back to
Chlorine Binding Sites List in 6v2f
Chlorine binding site 5 out
of 6 in the Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207 within 5.0Å range:
|
Chlorine binding site 6 out of 6 in 6v2f
Go back to
Chlorine Binding Sites List in 6v2f
Chlorine binding site 6 out
of 6 in the Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Crystal Structure of the Hiv Capsid Hexamer Bound to the Small Molecule Long-Acting Inhibitor, Gs-6207 within 5.0Å range:
|
Reference:
J.O.Link,
M.S.Rhee,
W.C.Tse,
J.Zheng,
J.R.Somoza,
W.Rowe,
R.Begley,
A.Chiu,
A.Mulato,
D.Hansen,
E.Singer,
L.K.Tsai,
R.A.Bam,
C.H.Chou,
E.Canales,
G.Brizgys,
J.R.Zhang,
J.Li,
M.Graupe,
P.Morganelli,
Q.Liu,
Q.Wu,
R.L.Halcomb,
R.D.Saito,
S.D.Schroeder,
S.E.Lazerwith,
S.Bondy,
D.Jin,
M.Hung,
N.Novikov,
X.Liu,
A.G.Villasenor,
C.E.Cannizzaro,
E.Y.Hu,
R.L.Anderson,
T.C.Appleby,
B.Lu,
J.Mwangi,
A.Liclican,
A.Niedziela-Majka,
G.A.Papalia,
M.H.Wong,
S.A.Leavitt,
Y.Xu,
D.Koditek,
G.J.Stepan,
H.Yu,
N.Pagratis,
S.Clancy,
S.Ahmadyar,
T.Z.Cai,
S.Sellers,
S.A.Wolckenhauer,
J.Ling,
C.Callebaut,
N.Margot,
R.R.Ram,
Y.P.Liu,
R.Hyland,
G.I.Sinclair,
P.J.Ruane,
G.E.Crofoot,
C.K.Mcdonald,
D.M.Brainard,
L.Lad,
S.Swaminathan,
W.I.Sundquist,
R.Sakowicz,
A.E.Chester,
W.E.Lee,
E.S.Daar,
S.R.Yant,
T.Cihlar.
Clinical Targeting of Hiv Capsid Protein with A Long-Acting Small Molecule. Nature V. 584 614 2020.
ISSN: ESSN 1476-4687
PubMed: 32612233
DOI: 10.1038/S41586-020-2443-1
Page generated: Mon Jul 29 16:03:41 2024
ISSN: ESSN 1476-4687
PubMed: 32612233
DOI: 10.1038/S41586-020-2443-1
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