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Chlorine in PDB 6vhg: Crystal Structure of Phosphorylated Ret Tyrosine Kinase Domain Complexed with A Pyrazolo[1,5-A]Pyrimidine InhibitorEnzymatic activity of Crystal Structure of Phosphorylated Ret Tyrosine Kinase Domain Complexed with A Pyrazolo[1,5-A]Pyrimidine Inhibitor
All present enzymatic activity of Crystal Structure of Phosphorylated Ret Tyrosine Kinase Domain Complexed with A Pyrazolo[1,5-A]Pyrimidine Inhibitor:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of Phosphorylated Ret Tyrosine Kinase Domain Complexed with A Pyrazolo[1,5-A]Pyrimidine Inhibitor, PDB code: 6vhg
was solved by
C.C.Lee,
G.Spraggon,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Phosphorylated Ret Tyrosine Kinase Domain Complexed with A Pyrazolo[1,5-A]Pyrimidine Inhibitor
(pdb code 6vhg). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Phosphorylated Ret Tyrosine Kinase Domain Complexed with A Pyrazolo[1,5-A]Pyrimidine Inhibitor, PDB code: 6vhg: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6vhgGo back to Chlorine Binding Sites List in 6vhg
Chlorine binding site 1 out
of 2 in the Crystal Structure of Phosphorylated Ret Tyrosine Kinase Domain Complexed with A Pyrazolo[1,5-A]Pyrimidine Inhibitor
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 6vhgGo back to Chlorine Binding Sites List in 6vhg
Chlorine binding site 2 out
of 2 in the Crystal Structure of Phosphorylated Ret Tyrosine Kinase Domain Complexed with A Pyrazolo[1,5-A]Pyrimidine Inhibitor
Mono view Stereo pair view
Reference:
C.J.N.Mathison,
D.Chianelli,
P.V.Rucker,
J.Nelson,
J.Roland,
Z.Huang,
Y.Yang,
H.Jiang,
Y.F.Xie,
R.Epple,
B.Bursuaya,
C.Lee,
M.-Y.Gao,
J.Shaffe,
S.Briones,
Y.Sarkisoa,
A.Galkin,
L.Li,
N.Li,
C.Li,
S.Hua,
S.Kasibhatla,
J.Kinyamu-Akunda,
R.Kikkawa,
V.Molteni,
J.E.Tellew.
Efficacy and Tolerability of Pyrazolo[1,5-A]Pyrimidine Ret Kinase Inhibitors For the Treatment of Lung Adenocarcinoma Acs Med.Chem.Lett. 2020.
Page generated: Sat Dec 12 14:18:35 2020
ISSN: ISSN 1948-5875 DOI: 10.1021/ACSMEDCHEMLETT.0C00015 |
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