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Chlorine in PDB 6vnd: Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636Enzymatic activity of Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636
All present enzymatic activity of Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636:
1.3.5.2; Protein crystallography data
The structure of Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636, PDB code: 6vnd
was solved by
A.Padyana,
L.Jin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6vnd:
The structure of Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636
(pdb code 6vnd). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636, PDB code: 6vnd: Chlorine binding site 1 out of 1 in 6vndGo back to Chlorine Binding Sites List in 6vnd
Chlorine binding site 1 out
of 1 in the Quaternary Complex of Human Dihydroorotate Dehydrogenase (Dhodh) with Flavin Mononucleotide (Fmn), Orotic Acid and Ag-636
Mono view Stereo pair view
Reference:
G.Mcdonald,
V.Chubukov,
J.Coco,
K.Truskowski,
R.Narayanaswamy,
S.Choe,
M.Steadman,
E.Artin,
A.K.Padyana,
L.Jin,
S.Ronseaux,
C.Locuson,
Z.P.Fan,
T.Erdmann,
A.Mann,
S.Hayes,
M.Fletcher,
K.Nellore,
S.S.Rao,
H.Subramanya,
S.R.Kunnam,
S.K.Panigrahi,
T.Anthony,
S.Gopinath,
Z.Sui,
N.Nagaraja,
L.Dang,
G.Lenz,
J.Hurov,
S.A.Biller,
J.Murtie,
K.M.Marks,
D.B.Ulanet.
Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed By Ag-636, A Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol.Cancer Ther. 2020.
Page generated: Sat Dec 12 14:22:54 2020
ISSN: ESSN 1538-8514 PubMed: 33082276 DOI: 10.1158/1535-7163.MCT-20-0550 |
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