Chlorine in PDB 6vpg: TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp

All present enzymatic activity of TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp:
2.7.11.1;

The structure of TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp, PDB code: 6vpg was solved by D.C.Lim, M.B.Yaffe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.08 / 2.64
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	83.562, 83.562, 114.516, 90.00, 90.00, 90.00
R / Rfree (%)	19.9 / 24.5

The structure of TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Chlorine atom in the TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp (pdb code 6vpg). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp, PDB code: 6vpg:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl403 b:0.2 occ:0.67 N A:ARG232 3.7 65.7 1.0 CB A:ASP229 3.7 95.7 1.0 CB A:ARG232 3.8 72.2 1.0 CB A:GLN231 4.0 90.2 1.0 OD2 A:ASP229 4.2 0.8 1.0 CA A:ARG232 4.3 63.7 1.0 OE1 A:GLN231 4.4 97.5 1.0 CG A:ASP229 4.5 0.3 1.0 C A:GLN231 4.5 74.7 1.0 CA A:GLN231 4.7 86.2 1.0 N A:GLN231 4.7 83.1 1.0 CA A:ASP229 4.8 83.0 1.0 CD A:ARG232 5.0 88.2 1.0 CG A:ARG232 5.0 79.6 1.0

Chlorine binding site 2 out of 2 in the TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of TPX2 Residues 7-20 Fused to Aurora A Residues 116-389 in Complex with Amp-Pnp within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl404 b:0.2 occ:1.00 O A:HOH502 3.7 67.1 1.0 NH2 A:ARG340 3.7 0.5 1.0 NH1 A:ARG340 4.1 0.3 1.0 CZ A:ARG340 4.4 0.6 1.0 OD1 A:ASN332 4.5 97.9 1.0

D.C.Lim, V.Joukov, T.J.Rettenmaier, A.Kumagai, W.G.Dunphy, J.A.Wells, M.B.Yaffe. Redox Priming Promotes Aurora A Activation During Mitosis. Sci.Signal. V. 13 2020.
ISSN: ESSN 1937-9145
PubMed: 32694171
DOI: 10.1126/SCISIGNAL.ABB6707