Chlorine in PDB 6w3u: APE1 Exonuclease Substrate Complex R237C

Enzymatic activity of APE1 Exonuclease Substrate Complex R237C

All present enzymatic activity of APE1 Exonuclease Substrate Complex R237C:
4.2.99.18;

Protein crystallography data

The structure of APE1 Exonuclease Substrate Complex R237C, PDB code: 6w3u was solved by B.D.Freudenthal, A.M.Whitaker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.76 / 2.40
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 71.177, 65.622, 91.717, 90.00, 110.52, 90.00
R / Rfree (%) 18.4 / 25

Other elements in 6w3u:

The structure of APE1 Exonuclease Substrate Complex R237C also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the APE1 Exonuclease Substrate Complex R237C (pdb code 6w3u). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the APE1 Exonuclease Substrate Complex R237C, PDB code: 6w3u:

Chlorine binding site 1 out of 1 in 6w3u

Go back to Chlorine Binding Sites List in 6w3u
Chlorine binding site 1 out of 1 in the APE1 Exonuclease Substrate Complex R237C


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of APE1 Exonuclease Substrate Complex R237C within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl403

b:83.2
occ:1.00
OD1 A:ASP163 3.2 78.2 1.0
CG A:ASP163 3.7 71.8 1.0
N A:ASP163 3.8 54.6 1.0
CD2 A:PHE162 3.8 48.6 1.0
NE2 A:GLN137 3.9 71.3 1.0
CB A:PHE162 4.0 49.4 1.0
CB A:ASP163 4.3 56.6 1.0
OD2 A:ASP163 4.3 68.7 1.0
CA A:PHE162 4.3 47.3 1.0
CD1 A:LEU140 4.4 58.3 1.0
CG A:PHE162 4.4 48.4 1.0
O A:CYS138 4.6 52.7 1.0
C A:PHE162 4.6 51.2 1.0
CA A:ASP163 4.6 54.7 1.0
CE2 A:PHE162 4.9 52.0 1.0

Reference:

A.M.Whitaker, W.J.Stark, T.S.Flynn, B.D.Freudenthal. Molecular and Structural Characterization of Disease-Associated APE1 Polymorphisms. Dna Repair (Amst.) V.1-92 02867 2020.
ISSN: ISSN 1568-7856
PubMed: 32454397
DOI: 10.1016/J.DNAREP.2020.102867
Page generated: Sat Dec 12 14:28:00 2020

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