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Atomistry » Chlorine » PDB 6wji-6wu8 » 6wpe | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 6wji-6wu8 » 6wpe » |
Chlorine in PDB 6wpe: Human IDO1 in Complex with Compound 4Enzymatic activity of Human IDO1 in Complex with Compound 4
All present enzymatic activity of Human IDO1 in Complex with Compound 4:
1.13.11.52; Protein crystallography data
The structure of Human IDO1 in Complex with Compound 4, PDB code: 6wpe
was solved by
C.A.Lesburg,
A.Lammens,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human IDO1 in Complex with Compound 4
(pdb code 6wpe). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Human IDO1 in Complex with Compound 4, PDB code: 6wpe: Jump to Chlorine binding site number: 1; 2; 3; 4; Chlorine binding site 1 out of 4 in 6wpeGo back to Chlorine Binding Sites List in 6wpe
Chlorine binding site 1 out
of 4 in the Human IDO1 in Complex with Compound 4
Mono view Stereo pair view
Chlorine binding site 2 out of 4 in 6wpeGo back to Chlorine Binding Sites List in 6wpe
Chlorine binding site 2 out
of 4 in the Human IDO1 in Complex with Compound 4
Mono view Stereo pair view
Chlorine binding site 3 out of 4 in 6wpeGo back to Chlorine Binding Sites List in 6wpe
Chlorine binding site 3 out
of 4 in the Human IDO1 in Complex with Compound 4
Mono view Stereo pair view
Chlorine binding site 4 out of 4 in 6wpeGo back to Chlorine Binding Sites List in 6wpe
Chlorine binding site 4 out
of 4 in the Human IDO1 in Complex with Compound 4
Mono view Stereo pair view
Reference:
D.Li,
I.Bharathan,
Y.Deng,
A.Achab,
B.Hopkins,
W.Yu,
H.Zhang,
S.Sanyal,
Q.Pu,
K.Liu,
J.Lim,
X.Fradera,
C.A.Lesburg,
A.Lammens,
T.Martinot,
A.Doty,
H.Ferguson,
E.B.Nickbarg,
M.Cheng,
P.Spacciapoli,
P.Geda,
X.Song,
N.Smotrov,
P.Abeywickrema,
C.L.Andrews,
C.Chamberlin,
O.Mabrouk,
P.Curran,
M.Richards,
P.Saradjian,
J.R.Miller,
I.Knemeyer,
K.Otte,
S.Vincent,
N.Sciammetta,
A.Pasternak,
D.J.Bennett,
Y.Han.
Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis and Improve Pharmacokinetics: Optimization of Tetrahydroquinoline Class of IDO1 Inhibitors Acs Med.Chem.Lett. 2021.
Page generated: Mon Jul 29 16:51:04 2024
ISSN: ISSN 1948-5875 DOI: 10.1021/ACSMEDCHEMLETT.0C00525 |
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