Chlorine in PDB 6wrz: Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove.

The structure of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove., PDB code: 6wrz was solved by G.Minasov, L.Shuvalova, M.Rosas-Lemus, J.S.Brunzelle, O.Kiryukhina, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.91 / 2.25
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	169.147, 169.147, 51.834, 90.00, 90.00, 120.00
R / Rfree (%)	16.2 / 19

The structure of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. (pdb code 6wrz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove., PDB code: 6wrz:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl7112 b:78.7 occ:1.00 N A:GLU6945 3.2 47.9 1.0 CB A:GLU6945 4.0 55.5 1.0 CA A:GLU6945 4.0 50.6 1.0 CA A:LYS6944 4.0 44.4 1.0 C A:LYS6944 4.1 45.9 1.0 CG A:GLU6945 4.3 63.4 1.0 C A:GLU6945 4.4 46.2 1.0 CB A:LYS6944 4.4 43.0 1.0 CD A:LYS6944 4.4 45.0 1.0 N A:GLY6946 4.4 45.9 1.0 CL A:CL7113 4.6 70.3 0.5

Chlorine binding site 2 out of 5 in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl7113 b:64.5 occ:0.50 CL A:CL7113 0.0 64.5 0.5 CL A:CL7113 2.0 70.3 0.5 N A:GLY6946 3.4 45.9 1.0 CB A:GLU6945 3.5 55.5 1.0 CA A:GLY6946 3.9 45.3 1.0 C A:GLU6945 4.4 46.2 1.0 CG A:GLU6945 4.4 63.4 1.0 CA A:GLU6945 4.5 50.6 1.0 O A:GLY6946 4.9 42.5 1.0 C A:GLY6946 5.0 43.7 1.0

Chlorine binding site 3 out of 5 in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl7113 b:70.3 occ:0.50 CL A:CL7113 0.0 70.3 0.5 CL A:CL7113 2.0 64.5 0.5 N A:GLY6946 3.5 45.9 1.0 CA A:GLY6946 3.6 45.3 1.0 CB A:GLU6945 4.4 55.5 1.0 CL A:CL7112 4.6 78.7 1.0 C A:GLU6945 4.7 46.2 1.0

Chlorine binding site 4 out of 5 in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl7114 b:98.4 occ:1.00 O A:HOH7216 3.7 55.1 1.0 CE1 A:HIS6984 4.0 50.0 1.0 O A:GLY7011 4.3 71.5 1.0 ND1 A:HIS6984 4.4 48.2 1.0 CD A:PRO7013 5.0 68.4 1.0

Chlorine binding site 5 out of 5 in the Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7- Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl4405 b:88.3 occ:0.70 ND1 B:HIS4336 3.5 75.7 1.0 N B:HIS4336 3.6 78.7 1.0 O B:GLY4341 3.6 0.2 1.0 CA B:ASP4335 3.8 83.1 1.0 CA B:GLY4341 4.0 0.7 1.0 C B:ASP4335 4.2 80.2 1.0 C B:GLY4341 4.3 0.8 1.0 CB B:ASP4335 4.3 90.5 1.0 CG B:HIS4336 4.4 77.0 1.0 CE1 B:HIS4336 4.4 72.0 1.0 CB B:HIS4336 4.5 76.0 1.0 CA B:HIS4336 4.7 80.6 1.0 OD1 B:ASP4335 4.7 90.9 1.0 CG B:ASP4335 4.7 92.9 1.0 O B:ILE4334 4.8 78.3 1.0 N B:ASP4335 4.8 81.2 1.0

G.Minasov, L.Shuvalova, M.Rosas-Lemus, J.S.Brunzelle, O.Kiryukhina, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid). Crystal Structure of NSP16-NSP10 Heterodimer From Sars-Cov-2 with 7-Methyl-Gpppa and S-Adenosyl-L-Homocysteine in the Active Site and Sulfates in the Mrna Binding Groove. To Be Published.