Chlorine in PDB 6x3x: Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam (pdb code 6x3x). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam, PDB code: 6x3x:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 6x3x

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Chlorine binding site 1 out of 4 in the Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl406

b:46.2
occ:1.00
 CL A:DZP406 0.0 46.2 1.0
C9 A:DZP406 1.9 46.2 1.0
C8 A:DZP406 2.9 46.2 1.0
C14 A:DZP406 2.9 46.2 1.0
O A:MET261 3.1 47.8 1.0
C A:MET261 3.4 47.8 1.0
CB A:MET261 3.5 47.8 1.0
CE A:MET261 3.6 47.8 1.0
CB A:ASN265 3.7 53.7 1.0
CD1 A:PHE289 3.8 45.1 1.0
CB A:PHE289 3.8 45.1 1.0
O A:LEU285 3.9 45.9 1.0
CA A:MET261 4.0 47.8 1.0
N A:THR262 4.0 50.1 1.0
CG A:PHE289 4.2 45.1 1.0
C7 A:DZP406 4.2 46.2 1.0
C13 A:DZP406 4.3 46.2 1.0
CA A:THR262 4.4 50.1 1.0
CG A:MET261 4.5 47.8 1.0
CG A:ASN265 4.5 53.7 1.0
CB A:LEU285 4.5 45.9 1.0
C A:LEU285 4.6 45.9 1.0
CA A:PHE289 4.7 45.1 1.0
C6 A:DZP406 4.8 46.2 1.0
CE1 A:PHE289 4.8 45.1 1.0
N A:ASN265 4.8 53.7 1.0
SD A:MET261 4.8 47.8 1.0
CA A:ASN265 4.8 53.7 1.0
N A:PHE289 4.9 45.1 1.0
CD2 A:LEU285 5.0 45.9 1.0
CA A:LEU285 5.0 45.9 1.0

Chlorine binding site 2 out of 4 in 6x3x

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Chlorine binding site 2 out of 4 in the Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl406

b:40.5
occ:1.00
 CL C:DZP406 0.0 40.5 1.0
C9 C:DZP406 1.9 40.5 1.0
C8 C:DZP406 2.8 40.5 1.0
C14 C:DZP406 2.9 40.5 1.0
O C:MET261 3.1 40.5 1.0
CB C:ASN265 3.4 44.7 1.0
CG C:MET261 3.4 40.5 1.0
O C:LEU285 3.6 41.2 1.0
CB C:LEU285 3.7 41.2 1.0
C C:MET261 3.7 40.5 1.0
CG C:ASN265 4.1 44.7 1.0
C C:LEU285 4.1 41.2 1.0
CB C:MET261 4.2 40.5 1.0
C7 C:DZP406 4.2 40.5 1.0
CB C:PHE289 4.2 39.1 1.0
C13 C:DZP406 4.3 40.5 1.0
CD2 C:PHE289 4.3 39.1 1.0
CA C:LEU285 4.3 41.2 1.0
SD C:MET261 4.3 40.5 1.0
CD1 C:LEU285 4.3 41.2 1.0
CG C:LEU285 4.4 41.2 1.0
CA C:MET261 4.4 40.5 1.0
CA C:ASN265 4.4 44.7 1.0
N C:THR262 4.4 40.9 1.0
CD2 C:LEU285 4.5 41.2 1.0
N C:ASN265 4.5 44.7 1.0
ND2 C:ASN265 4.5 44.7 1.0
CG C:PHE289 4.6 39.1 1.0
CA C:THR262 4.7 40.9 1.0
OD1 C:ASN265 4.8 44.7 1.0
C6 C:DZP406 4.8 40.5 1.0

Chlorine binding site 3 out of 4 in 6x3x

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Chlorine binding site 3 out of 4 in the Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl404

b:22.1
occ:1.00
 CL D:DZP404 0.0 22.1 1.0
C9 D:DZP404 1.9 22.1 1.0
C14 D:DZP404 2.9 22.1 1.0
C8 D:DZP404 2.9 22.1 1.0
O D:HIS102 3.0 23.5 1.0
ND1 D:HIS102 3.4 23.5 1.0
CB D:HIS102 3.6 23.5 1.0
CA D:HIS102 3.6 23.5 1.0
C D:HIS102 3.7 23.5 1.0
CG D:HIS102 3.8 23.5 1.0
ND2 E:ASN60 4.0 23.7 1.0
CZ E:PHE77 4.1 19.8 1.0
OD1 E:ASN60 4.1 23.7 1.0
CE2 E:PHE77 4.2 19.8 1.0
C7 D:DZP404 4.2 22.1 1.0
C13 D:DZP404 4.2 22.1 1.0
CG E:ASN60 4.3 23.7 1.0
CE1 D:HIS102 4.5 23.5 1.0
CE2 D:PHE100 4.6 34.8 1.0
NH1 E:ARG144 4.7 18.9 1.0
C6 D:DZP404 4.8 22.1 1.0
CZ D:PHE100 4.8 34.8 1.0
N D:ASN103 5.0 23.2 1.0

Chlorine binding site 4 out of 4 in 6x3x

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Chlorine binding site 4 out of 4 in the Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Human Gabaa Receptor ALPHA1-BETA2-GAMMA2 Subtype in Complex with Gaba Plus Diazepam within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl403

b:50.2
occ:1.00
 CL E:DZP403 0.0 50.2 1.0
C9 E:DZP403 1.9 50.2 1.0
C8 E:DZP403 2.8 50.2 1.0
C14 E:DZP403 2.9 50.2 1.0
OD1 E:ASP297 3.5 49.5 1.0
CB E:ASP297 3.5 49.5 1.0
CA E:ASP297 3.5 49.5 1.0
CG E:ASP297 3.5 49.5 1.0
C7 E:DZP403 4.2 50.2 1.0
O E:ASP297 4.2 49.5 1.0
C13 E:DZP403 4.3 50.2 1.0
OD2 E:ASP297 4.3 49.5 1.0
CD E:ARG284 4.3 52.8 1.0
C E:ASP297 4.4 49.5 1.0
CG A:LEU223 4.4 46.1 1.0
CD1 A:LEU223 4.5 46.1 1.0
N E:ASP297 4.6 49.5 1.0
O A:LEU223 4.7 46.1 1.0
NE E:ARG284 4.7 52.8 1.0
CD2 A:LEU223 4.8 46.1 1.0
C6 E:DZP403 4.8 50.2 1.0
OG E:SER301 4.8 46.7 1.0
CB E:ARG284 4.8 52.8 1.0
CG E:ARG284 4.8 52.8 1.0
OE1 A:GLN224 4.9 46.7 1.0
CB E:VAL300 5.0 45.6 1.0
O E:MET296 5.0 48.6 1.0

Reference:

J.J.Kim, A.Gharpure, J.Teng, Y.Zhuang, R.J.Howard, S.Zhu, C.M.Noviello, R.M.Walsh Jr., E.Lindahl, R.E.Hibbs. Shared Structural Mechanisms of General Anaesthetics and Benzodiazepines. Nature V. 585 303 2020.
ISSN: ESSN 1476-4687
PubMed: 32879488
DOI: 10.1038/S41586-020-2654-5
Page generated: Sat Dec 12 14:33:21 2020

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