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Chlorine in PDB 6x4a: Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)- Yl)Ethoxy)Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non- Nucleoside InhibitorEnzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)- Yl)Ethoxy)Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non- Nucleoside Inhibitor
All present enzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)- Yl)Ethoxy)Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non- Nucleoside Inhibitor:
2.7.7.49; 2.7.7.7; 3.1.26.13; Protein crystallography data
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)- Yl)Ethoxy)Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non- Nucleoside Inhibitor, PDB code: 6x4a
was solved by
A.H.Chan,
V.N.Duong,
J.A.Ippolito,
W.L.Jorgensen,
K.S.Anderson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)- Yl)Ethoxy)Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non- Nucleoside Inhibitor
(pdb code 6x4a). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)- Yl)Ethoxy)Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non- Nucleoside Inhibitor, PDB code: 6x4a: Chlorine binding site 1 out of 1 in 6x4aGo back to Chlorine Binding Sites List in 6x4a
Chlorine binding site 1 out
of 1 in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-Chloro-7-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)- Yl)Ethoxy)Phenoxy)-8-Methyl-2-Naphthonitrile (JLJ651), A Non- Nucleoside Inhibitor
Mono view Stereo pair view
Reference:
V.N.Duong,
J.A.Ippolito,
A.H.Chan,
W.G.Lee,
K.A.Spasov,
W.L.Jorgensen,
K.S.Anderson.
Structural Investigation of 2-Naphthyl Phenyl Ether Inhibitors Bound to Wt and Y181C Reverse Transcriptase Highlights Key Features of the Nnrti Binding Site. Protein Sci. 2020.
Page generated: Sat Dec 12 14:33:49 2020
ISSN: ESSN 1469-896X PubMed: 32643196 DOI: 10.1002/PRO.3910 |
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