Chlorine in PDB 6x7v: Crystal Structure of the Human Nudix Hydrolase NUDT16

All present enzymatic activity of Crystal Structure of the Human Nudix Hydrolase NUDT16:
3.6.1.62; 3.6.1.64;

The structure of Crystal Structure of the Human Nudix Hydrolase NUDT16, PDB code: 6x7v was solved by K.Hamilton, L.Tong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.28 / 2.30
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	85.686, 137.922, 54.990, 90.00, 90.00, 90.00
R / Rfree (%)	22.4 / 28.7

The structure of Crystal Structure of the Human Nudix Hydrolase NUDT16 also contains other interesting chemical elements:

Manganese

(Mn)

1 atom

The binding sites of Chlorine atom in the Crystal Structure of the Human Nudix Hydrolase NUDT16 (pdb code 6x7v). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Human Nudix Hydrolase NUDT16, PDB code: 6x7v:

Chlorine binding site 1 out of 1 in the Crystal Structure of the Human Nudix Hydrolase NUDT16


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Human Nudix Hydrolase NUDT16 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl201 b:52.0 occ:1.00 O D:HOH317 3.2 51.5 1.0 N D:ARG149 3.4 51.4 1.0 O A:HOH303 3.4 52.0 1.0 N A:MET34 3.5 57.6 1.0 CB D:ARG149 3.7 55.9 1.0 CB D:LEU148 3.8 49.3 1.0 CG D:ARG149 3.9 54.5 1.0 CA A:GLY33 4.1 54.5 1.0 CD2 D:LEU148 4.1 40.0 1.0 NH1 D:ARG38 4.1 66.4 1.0 CA D:ARG149 4.1 53.9 1.0 CB A:MET34 4.3 60.1 1.0 CA D:LEU148 4.3 55.9 1.0 C A:GLY33 4.3 57.1 1.0 C D:LEU148 4.3 50.6 1.0 O A:MET34 4.3 58.5 1.0 CG D:LEU148 4.4 54.9 1.0 CA A:MET34 4.4 57.2 1.0 CG A:MET34 4.5 61.2 1.0 CD1 D:LEU148 4.6 52.9 1.0 O A:PRO32 4.6 55.5 1.0 C A:MET34 4.7 59.7 1.0 O D:HOH324 5.0 54.4 1.0

S.Sharma, E.Grudzien-Nogalska, K.Hamilton, X.Jiao, J.Yang, L.Tong, M.Kiledjian. Mammalian Nudix Proteins Cleave Nucleotide Metabolite Caps on Rnas. Nucleic Acids Res. V. 48 6788 2020.
ISSN: ESSN 1362-4962
PubMed: 32432673
DOI: 10.1093/NAR/GKAA402