Chlorine in PDB 6xq6: Receptor For Advanced Glycation End Products VC1 Domain in Complex with Fragment 11

The structure of Receptor For Advanced Glycation End Products VC1 Domain in Complex with Fragment 11, PDB code: 6xq6 was solved by L.E.Salay, N.Kozlyuk, B.A.Gilston, R.D.Gogliotti, P.P.Christov, K.Kim, M.Ovee, A.G.Waterson, W.J.Chazin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.44 / 1.90
Space group	P 62
Cell size a, b, c (Å), α, β, γ (°)	101.376, 101.376, 104.025, 90, 90, 120
R / Rfree (%)	19.5 / 22.1

The binding sites of Chlorine atom in the Receptor For Advanced Glycation End Products VC1 Domain in Complex with Fragment 11 (pdb code 6xq6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Receptor For Advanced Glycation End Products VC1 Domain in Complex with Fragment 11, PDB code: 6xq6:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Receptor For Advanced Glycation End Products VC1 Domain in Complex with Fragment 11


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Receptor For Advanced Glycation End Products VC1 Domain in Complex with Fragment 11 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl305 b:23.7 occ:1.00 O A:HOH470 3.1 33.2 1.0 N A:GLU59 3.2 19.1 1.0 CA A:THR58 3.8 16.7 1.0 O A:GLU59 3.9 19.9 1.0 CB A:THR58 3.9 17.0 1.0 C A:THR58 4.0 17.0 1.0 CB A:GLU59 4.0 20.0 1.0 CA A:GLU59 4.1 20.4 1.0 CB A:LYS62 4.2 18.4 1.0 C A:GLU59 4.4 21.2 1.0 CD A:LYS62 4.5 28.0 1.0 CG2 A:THR58 4.6 17.1 1.0 O A:HOH481 4.7 39.7 1.0 O A:ARG57 4.8 26.4 1.0 CA A:LYS62 4.9 18.0 1.0 CG A:LYS62 4.9 21.9 1.0 O A:TRP61 5.0 20.2 1.0

Chlorine binding site 2 out of 2 in the Receptor For Advanced Glycation End Products VC1 Domain in Complex with Fragment 11


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Receptor For Advanced Glycation End Products VC1 Domain in Complex with Fragment 11 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl304 b:24.5 occ:1.00 N B:GLU59 3.2 18.8 1.0 CA B:THR58 3.8 16.2 1.0 CB B:THR58 3.9 18.0 1.0 C B:THR58 4.0 16.6 1.0 O B:GLU59 4.0 20.2 1.0 CB B:GLU59 4.1 21.5 1.0 CA B:GLU59 4.1 19.2 1.0 CB B:LYS62 4.2 19.1 1.0 C B:GLU59 4.4 18.4 1.0 CD B:LYS62 4.5 27.3 1.0 CG2 B:THR58 4.5 17.6 1.0 O B:ARG57 4.8 27.8 1.0 CA B:LYS62 4.9 18.7 1.0 CG B:LYS62 4.9 22.2 1.0 O B:TRP61 5.0 20.9 1.0

N.Kozlyuk, B.A.Gilston, L.E.Salay, R.D.Gogliotti, P.P.Christov, K.Kim, M.Ovee, A.G.Waterson, W.J.Chazin. A Fragment-Based Approach to Discovery of Rage Inhibitors To Be Published.