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Chlorine in PDB 6xue: Human Ecto-5'-Nucleotidase (CD73) in Complex with A2396 (Compound 74 in Publication) in the Closed Form in Crystal Form IVEnzymatic activity of Human Ecto-5'-Nucleotidase (CD73) in Complex with A2396 (Compound 74 in Publication) in the Closed Form in Crystal Form IV
All present enzymatic activity of Human Ecto-5'-Nucleotidase (CD73) in Complex with A2396 (Compound 74 in Publication) in the Closed Form in Crystal Form IV:
3.1.3.5; Protein crystallography data
The structure of Human Ecto-5'-Nucleotidase (CD73) in Complex with A2396 (Compound 74 in Publication) in the Closed Form in Crystal Form IV, PDB code: 6xue
was solved by
N.Strater,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6xue:
The structure of Human Ecto-5'-Nucleotidase (CD73) in Complex with A2396 (Compound 74 in Publication) in the Closed Form in Crystal Form IV also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human Ecto-5'-Nucleotidase (CD73) in Complex with A2396 (Compound 74 in Publication) in the Closed Form in Crystal Form IV
(pdb code 6xue). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Ecto-5'-Nucleotidase (CD73) in Complex with A2396 (Compound 74 in Publication) in the Closed Form in Crystal Form IV, PDB code: 6xue: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6xueGo back to Chlorine Binding Sites List in 6xue
Chlorine binding site 1 out
of 2 in the Human Ecto-5'-Nucleotidase (CD73) in Complex with A2396 (Compound 74 in Publication) in the Closed Form in Crystal Form IV
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 6xueGo back to Chlorine Binding Sites List in 6xue
Chlorine binding site 2 out
of 2 in the Human Ecto-5'-Nucleotidase (CD73) in Complex with A2396 (Compound 74 in Publication) in the Closed Form in Crystal Form IV
Mono view Stereo pair view
Reference:
J.W.Beatty,
E.A.Lindsey,
R.Thomas-Tran,
L.Debien,
D.Mandal,
J.L.Jeffrey,
A.T.Tran,
J.Fournier,
S.D.Jacob,
X.Yan,
S.L.Drew,
E.Ginn,
A.Chen,
A.T.Pham,
S.Zhao,
L.Jin,
S.W.Young,
N.P.Walker,
M.R.Leleti,
S.Moschutz,
N.Strater,
J.P.Powers,
K.V.Lawson.
Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73. J.Med.Chem. 2020.
Page generated: Sat Dec 12 14:37:31 2020
ISSN: ISSN 0022-2623 PubMed: 32212732 DOI: 10.1021/ACS.JMEDCHEM.9B01713 |
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