Chlorine in PDB 6yh2: Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One

Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One

All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6yh2 was solved by A.Nguyen, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.10 / 1.19
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.724, 65.338, 70.909, 90.00, 96.13, 90.00
R / Rfree (%) 11.9 / 13.5

Other elements in 6yh2:

The structure of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One also contains other interesting chemical elements:

Fluorine (F) 4 atoms
Zinc (Zn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One (pdb code 6yh2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6yh2:

Chlorine binding site 1 out of 1 in 6yh2

Go back to Chlorine Binding Sites List in 6yh2
Chlorine binding site 1 out of 1 in the Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Trna-Guanine Transglycosylase (Tgt) Labeled with 5-Fluorotryptophan in Co-Crystallized Complex with 2-(Methylamino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl405

b:18.8
occ:0.80
 HG1 A:THR285 2.2 17.6 1.0
HH12 A:ARG289 2.4 20.8 1.0
O A:HOH690 2.7 30.4 1.0
HD2 A:LYS52 3.0 21.6 1.0
OG1 A:THR285 3.0 14.7 1.0
HB A:THR285 3.0 17.2 1.0
HH22 A:ARG289 3.1 24.3 1.0
O A:HOH570 3.2 21.8 1.0
NH1 A:ARG289 3.2 17.3 1.0
HB A:VAL282 3.2 18.1 1.0
HB2 A:ARG286 3.3 21.1 0.5
HB2 A:ARG286 3.3 20.1 0.6
CB A:THR285 3.5 14.3 1.0
H A:ARG286 3.6 17.9 0.5
H A:ARG286 3.6 17.5 0.6
HH11 A:ARG289 3.7 20.8 1.0
NH2 A:ARG289 3.8 20.2 1.0
N A:ARG286 3.8 14.9 0.5
N A:ARG286 3.8 14.6 0.6
CD A:LYS52 3.8 18.0 1.0
HG12 A:VAL282 3.9 20.5 1.0
HB2 A:LYS52 3.9 17.1 1.0
CZ A:ARG289 4.0 18.8 1.0
HE2 A:LYS52 4.0 26.2 1.0
HA A:ARG286 4.0 19.4 0.5
HE3 A:LYS52 4.0 26.2 1.0
HA A:ARG286 4.0 18.9 0.6
CB A:VAL282 4.1 15.1 1.0
HG3 A:LYS52 4.1 18.6 1.0
HG11 A:VAL282 4.1 20.5 1.0
CB A:ARG286 4.2 17.6 0.5
CB A:ARG286 4.2 16.8 0.6
HE A:ARG286 4.2 30.1 0.5
CE A:LYS52 4.2 21.8 1.0
CG1 A:VAL282 4.2 17.1 1.0
CA A:ARG286 4.2 16.2 0.5
CA A:ARG286 4.3 15.7 0.6
HA A:VAL282 4.3 16.0 1.0
C A:THR285 4.3 14.5 1.0
O A:VAL282 4.4 14.1 1.0
CG A:LYS52 4.4 15.5 1.0
HG21 A:THR285 4.4 18.8 1.0
OG1 A:THR47 4.5 25.7 1.0
CA A:THR285 4.5 14.1 1.0
HD3 A:LYS52 4.5 21.6 1.0
HH21 A:ARG289 4.6 24.3 1.0
HB A:VAL45 4.6 15.4 1.0
CG2 A:THR285 4.6 15.6 1.0
CB A:LYS52 4.6 14.2 1.0
CA A:VAL282 4.7 13.3 1.0
HB3 A:ARG286 4.7 20.1 0.6
H A:LYS52 4.7 14.3 1.0
HB3 A:ARG286 4.7 21.1 0.5
HD3 A:ARG286 4.8 25.7 0.6
HH21 A:ARG286 4.8 33.1 0.5
O A:HOH665 4.9 15.5 1.0
NE A:ARG286 4.9 25.1 0.5
HG3 A:ARG286 5.0 23.9 0.5

Reference:

A.Nguyen, A.Heine, G.Klebe. Co-Crystallization, Nanoesi-Ms and 19F uc(Nmr) Reveal Dimer Disturbing Inhibitors and Conformational Changes at Dimer Contacts To Be Published.
Page generated: Sat Dec 12 14:42:56 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy