Chlorine in PDB 6yk2: Structure of the Ampa Receptor GLUA2O Ligand-Binding Domain (S1S2J) in Complex with the Compound (S)-1-[2'-Amino-2'-Carboxyethyl]-5,7- Dihydrothieno[3,4-D]Pyrimidin- 2,4(1H,3H)-Dione at Resolution 1.60A

The structure of Structure of the Ampa Receptor GLUA2O Ligand-Binding Domain (S1S2J) in Complex with the Compound (S)-1-[2'-Amino-2'-Carboxyethyl]-5,7- Dihydrothieno[3,4-D]Pyrimidin- 2,4(1H,3H)-Dione at Resolution 1.60A, PDB code: 6yk2 was solved by K.Frydenvang, J.S.Kastrup, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.06 / 1.61
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	59.274, 96.530, 48.711, 90.00, 90.00, 90.00
R / Rfree (%)	14.5 / 16.3

The binding sites of Chlorine atom in the Structure of the Ampa Receptor GLUA2O Ligand-Binding Domain (S1S2J) in Complex with the Compound (S)-1-[2'-Amino-2'-Carboxyethyl]-5,7- Dihydrothieno[3,4-D]Pyrimidin- 2,4(1H,3H)-Dione at Resolution 1.60A (pdb code 6yk2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of the Ampa Receptor GLUA2O Ligand-Binding Domain (S1S2J) in Complex with the Compound (S)-1-[2'-Amino-2'-Carboxyethyl]-5,7- Dihydrothieno[3,4-D]Pyrimidin- 2,4(1H,3H)-Dione at Resolution 1.60A, PDB code: 6yk2:

Chlorine binding site 1 out of 1 in the Structure of the Ampa Receptor GLUA2O Ligand-Binding Domain (S1S2J) in Complex with the Compound (S)-1-[2'-Amino-2'-Carboxyethyl]-5,7- Dihydrothieno[3,4-D]Pyrimidin- 2,4(1H,3H)-Dione at Resolution 1.60A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of the Ampa Receptor GLUA2O Ligand-Binding Domain (S1S2J) in Complex with the Compound (S)-1-[2'-Amino-2'-Carboxyethyl]-5,7- Dihydrothieno[3,4-D]Pyrimidin- 2,4(1H,3H)-Dione at Resolution 1.60A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl310 b:58.3 occ:1.00 N A:THR5 3.3 17.2 1.0 OG1 A:THR5 3.7 20.1 1.0 CB A:THR5 3.8 18.5 1.0 O A:HOH568 3.9 28.4 1.0 CA A:LYS4 4.0 22.9 1.0 CB A:LYS4 4.0 23.4 1.0 CA A:THR5 4.1 16.1 1.0 C A:LYS4 4.1 21.9 1.0 CG A:LYS4 4.6 28.4 1.0 O A:THR5 4.8 15.1 1.0 C A:THR5 5.0 13.4 1.0

K.Frydenvang, D.S.Pickering, G.U.Kshirsagar, G.Chemi, S.Gemma, D.Sprogoe, A.M.KæRn, S.Brogi, G.Campiani, S.Butini, J.S.Kastrup. The Ionotropic Glutamate Receptor GLUA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions. Acs Chem Neurosci 2020.
ISSN: ESSN 1948-7193
PubMed: 32437601
DOI: 10.1021/ACSCHEMNEURO.0C00195