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Chlorine in PDB 6z10: Crystal Structure of A Humanized (K18E, K269N) Rat Succinate Receptor SUCNR1 (GPR91) in Complex with A Nanobody and AntagonistProtein crystallography data
The structure of Crystal Structure of A Humanized (K18E, K269N) Rat Succinate Receptor SUCNR1 (GPR91) in Complex with A Nanobody and Antagonist, PDB code: 6z10
was solved by
M.Haffke,
F.Villard,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6z10:
The structure of Crystal Structure of A Humanized (K18E, K269N) Rat Succinate Receptor SUCNR1 (GPR91) in Complex with A Nanobody and Antagonist also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of A Humanized (K18E, K269N) Rat Succinate Receptor SUCNR1 (GPR91) in Complex with A Nanobody and Antagonist
(pdb code 6z10). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of A Humanized (K18E, K269N) Rat Succinate Receptor SUCNR1 (GPR91) in Complex with A Nanobody and Antagonist, PDB code: 6z10: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6z10Go back to Chlorine Binding Sites List in 6z10
Chlorine binding site 1 out
of 2 in the Crystal Structure of A Humanized (K18E, K269N) Rat Succinate Receptor SUCNR1 (GPR91) in Complex with A Nanobody and Antagonist
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 6z10Go back to Chlorine Binding Sites List in 6z10
Chlorine binding site 2 out
of 2 in the Crystal Structure of A Humanized (K18E, K269N) Rat Succinate Receptor SUCNR1 (GPR91) in Complex with A Nanobody and Antagonist
Mono view Stereo pair view
Reference:
J.Velcicky,
R.Wilcken,
S.Cotesta,
P.Janser,
A.Schlapbach,
T.Wagner,
P.Piechon,
F.Villard,
R.Bouhelal,
F.Piller,
S.Harlfinger,
R.Stringer,
D.Fehlmann,
K.Kaupmann,
A.Littlewood-Evans,
M.Haffke,
N.Gommermann.
Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with A Salt Bridge For the Improvement of Oral Exposure. J.Med.Chem. V. 63 9856 2020.
Page generated: Sat Dec 12 14:45:00 2020
ISSN: ISSN 0022-2623 PubMed: 32856916 DOI: 10.1021/ACS.JMEDCHEM.0C01020 |
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