Chlorine in PDB 6z31: Human Cation-Independent Mannose 6-Phosphate/ IGF2 Receptor Domain 8

The structure of Human Cation-Independent Mannose 6-Phosphate/ IGF2 Receptor Domain 8, PDB code: 6z31 was solved by A.J.Bochel, C.Williams, M.P.Crump, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.02 / 2.56
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	65.555, 45.537, 70.275, 90.00, 116.36, 90.00
R / Rfree (%)	22.3 / 25.1

The structure of Human Cation-Independent Mannose 6-Phosphate/ IGF2 Receptor Domain 8 also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Chlorine atom in the Human Cation-Independent Mannose 6-Phosphate/ IGF2 Receptor Domain 8 (pdb code 6z31). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Cation-Independent Mannose 6-Phosphate/ IGF2 Receptor Domain 8, PDB code: 6z31:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human Cation-Independent Mannose 6-Phosphate/ IGF2 Receptor Domain 8


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Cation-Independent Mannose 6-Phosphate/ IGF2 Receptor Domain 8 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1301 b:46.2 occ:1.00 CL B:CL1301 3.3 40.8 1.0 N A:ARG1103 3.3 43.1 1.0 N A:VAL1102 3.6 47.2 1.0 N A:LYS1104 3.9 30.9 1.0 CB A:ARG1103 4.0 26.3 1.0 CB A:VAL1102 4.0 50.9 1.0 O A:LYS1104 4.1 30.4 1.0 CG1 A:VAL1102 4.1 43.1 1.0 CG A:LYS1104 4.1 27.1 1.0 CA A:ARG1103 4.1 33.0 1.0 CA A:VAL1102 4.1 55.5 1.0 O B:HOH1408 4.1 33.9 1.0 C A:VAL1102 4.2 58.0 1.0 CE B:LYS1104 4.2 29.6 1.0 CE A:LYS1104 4.4 30.1 1.0 O A:HOH1402 4.4 36.8 1.0 C A:ARG1103 4.5 34.2 1.0 C A:THR1101 4.5 64.3 1.0 NZ B:LYS1104 4.5 34.2 1.0 CA A:THR1101 4.7 66.0 1.0 CA A:LYS1104 4.8 27.8 1.0 NZ A:LYS1104 4.9 32.2 1.0 O A:SER1100 4.9 41.1 1.0 CD A:LYS1104 4.9 26.8 1.0 C A:LYS1104 4.9 32.0 1.0

Chlorine binding site 2 out of 2 in the Human Cation-Independent Mannose 6-Phosphate/ IGF2 Receptor Domain 8


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Cation-Independent Mannose 6-Phosphate/ IGF2 Receptor Domain 8 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1301 b:40.8 occ:1.00 CL A:CL1301 3.3 46.2 1.0 CG2 B:VAL1102 3.3 53.9 1.0 N B:ARG1103 3.4 40.8 1.0 N B:LYS1104 3.7 27.2 1.0 CG B:LYS1104 3.8 23.8 1.0 N B:VAL1102 3.9 53.2 1.0 O A:HOH1402 3.9 36.8 1.0 CB B:ARG1103 4.0 28.2 1.0 CA B:ARG1103 4.1 33.0 1.0 O B:LYS1104 4.1 27.1 1.0 CE A:LYS1104 4.2 30.1 1.0 CB B:VAL1102 4.3 50.9 1.0 C B:VAL1102 4.4 52.5 1.0 CA B:VAL1102 4.4 56.8 1.0 C B:ARG1103 4.4 30.5 1.0 NZ A:LYS1104 4.4 32.2 1.0 CE B:LYS1104 4.4 29.6 1.0 O B:HOH1408 4.6 33.9 1.0 CA B:LYS1104 4.6 28.7 1.0 NZ B:LYS1104 4.7 34.2 1.0 CD B:LYS1104 4.8 25.2 1.0 CB B:LYS1104 4.8 23.5 1.0 C B:THR1101 4.8 48.4 1.0 CG1 B:VAL1102 4.8 57.4 1.0 C B:LYS1104 4.8 29.4 1.0 CA B:THR1101 4.9 51.0 1.0

A.J.Bochel, C.Williams, A.J.Mccoy, H.J.Hoppe, A.J.Winter, R.D.Nicholls, K.Harlos, E.Y.Jones, I.Berger, A.B.Hassan, M.P.Crump. Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9. Structure V. 28 1300 2020.
ISSN: ISSN 0969-2126
PubMed: 32877646
DOI: 10.1016/J.STR.2020.08.002