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Chlorine in PDB 6z9b: Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III)Enzymatic activity of Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III)
All present enzymatic activity of Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III):
3.1.3.5; Protein crystallography data
The structure of Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III), PDB code: 6z9b
was solved by
N.Strater,
E.Scaletti,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6z9b:
The structure of Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III) also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III)
(pdb code 6z9b). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III), PDB code: 6z9b: Chlorine binding site 1 out of 1 in 6z9bGo back to Chlorine Binding Sites List in 6z9b
Chlorine binding site 1 out
of 1 in the Human Ecto-5'-Nucleotidase (CD73) in Complex with Aopcp Derivative A830 (Compound 16 in Publication) in the Closed Form (Crystal Form III)
Mono view Stereo pair view
Reference:
K.V.Lawson,
J.Kalisiak,
E.A.Lindsey,
E.T.Newcomb,
M.R.Leleti,
L.Debien,
B.R.Rosen,
D.H.Miles,
E.U.Sharif,
J.L.Jeffrey,
J.B.L.Tan,
A.Chen,
S.Zhao,
G.Xu,
L.Fu,
L.Jin,
T.W.Park,
W.Berry,
S.Moschutz,
E.Scaletti,
N.Strater,
N.P.Walker,
S.W.Young,
M.J.Walters,
U.Schindler,
J.P.Powers.
Discovery of AB680: A Potent and Selective Inhibitor of CD73. J.Med.Chem. V. 63 11448 2020.
Page generated: Sat Dec 12 14:46:05 2020
ISSN: ISSN 0022-2623 PubMed: 32614585 DOI: 10.1021/ACS.JMEDCHEM.0C00525 |
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