Chlorine in PDB 6zep: Flavourzyme Leucine Aminopeptidase A Proenzyme

The structure of Flavourzyme Leucine Aminopeptidase A Proenzyme, PDB code: 6zep was solved by K.A.Watson, G.Baltulionis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.61 / 1.61
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	43.43, 94.39, 99.11, 90, 90, 90
R / Rfree (%)	15.3 / 17.4

The structure of Flavourzyme Leucine Aminopeptidase A Proenzyme also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Flavourzyme Leucine Aminopeptidase A Proenzyme (pdb code 6zep). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Flavourzyme Leucine Aminopeptidase A Proenzyme, PDB code: 6zep:

Chlorine binding site 1 out of 1 in the Flavourzyme Leucine Aminopeptidase A Proenzyme


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Flavourzyme Leucine Aminopeptidase A Proenzyme within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl411 b:50.5 occ:1.00 O A:HOH800 2.1 24.3 1.0 ZN A:ZN410 2.4 20.9 1.0 NH2 A:ARG55 2.4 43.0 0.6 O A:HOH693 2.6 20.1 1.0 O A:HOH829 2.6 43.0 1.0 O A:HOH735 2.8 39.3 1.0 OD2 A:ASP195 3.1 17.7 1.0 NE2 A:HIS343 3.3 22.8 1.0 CE1 A:HIS343 3.4 25.9 1.0 ZN A:ZN409 3.5 16.9 1.0 CZ A:ARG55 3.7 42.9 0.6 CG A:ASP195 3.8 16.2 1.0 CD1 A:ILE342 3.9 22.8 1.0 OD1 A:ASP195 4.0 17.3 1.0 O A:HOH730 4.1 32.1 1.0 NH2 A:ARG50 4.3 42.9 1.0 OE1 A:GLU234 4.4 20.0 1.0 SD A:MET262 4.4 20.1 1.0 NE A:ARG55 4.4 41.4 0.6 NH1 A:ARG55 4.5 47.1 0.6 CD2 A:HIS343 4.5 17.6 1.0 OE2 A:GLU234 4.6 21.1 1.0 ND1 A:HIS343 4.7 24.4 1.0 OD2 A:ASP261 4.7 19.7 1.0 CD A:GLU234 4.9 23.0 1.0 O A:HOH623 5.0 38.3 1.0

G.Baltulionis, M.Blight, A.Robin, D.Charalampopoulos, K.A.Watson. The Role of Propeptide-Mediated Autoinhibition and Intermolecular Chaperone in the Maturation of Cognate Catalytic Domain in Leucine Aminopeptidase. J.Struct.Biol. V. 213 07741 2021.
ISSN: ESSN 1095-8657
PubMed: 33989771
DOI: 10.1016/J.JSB.2021.107741