Chlorine in PDB 6zpe: Nonstructural Protein 10 (NSP10) From Sars Cov-2

All present enzymatic activity of Nonstructural Protein 10 (NSP10) From Sars Cov-2:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13;

The structure of Nonstructural Protein 10 (NSP10) From Sars Cov-2, PDB code: 6zpe was solved by S.Z.Fisher, F.Kozielski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.53 / 1.58
Space group	I 21 3
Cell size a, b, c (Å), α, β, γ (°)	106.624, 106.624, 106.624, 90.00, 90.00, 90.00
R / Rfree (%)	15.2 / 16

The structure of Nonstructural Protein 10 (NSP10) From Sars Cov-2 also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Nonstructural Protein 10 (NSP10) From Sars Cov-2 (pdb code 6zpe). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Nonstructural Protein 10 (NSP10) From Sars Cov-2, PDB code: 6zpe:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Nonstructural Protein 10 (NSP10) From Sars Cov-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Nonstructural Protein 10 (NSP10) From Sars Cov-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl204 b:44.0 occ:1.00 O A:HOH362 3.1 37.3 1.0 O A:HOH439 3.2 49.4 1.0 N A:GLY127 3.2 48.0 1.0 NE2 A:GLN65 3.3 34.7 1.0 CD1 A:TRP123 3.7 32.2 1.0 CA A:GLY127 3.7 48.0 1.0 CB A:TYR126 3.7 39.1 1.0 CG A:PRO100 3.9 35.9 1.0 CB A:TRP123 4.1 34.3 1.0 C A:TYR126 4.3 47.5 1.0 CG A:TRP123 4.3 30.8 1.0 CD A:PRO100 4.3 31.6 1.0 CD A:GLN65 4.3 33.5 1.0 N A:TRP123 4.5 36.0 1.0 CG A:GLN65 4.5 30.6 1.0 CA A:TYR126 4.6 44.3 1.0 O A:HOH393 4.7 53.2 1.0 CE A:MET122 4.8 53.1 1.0 O A:GLY52 4.8 33.7 1.0 CA A:TRP123 4.8 33.1 1.0 NE1 A:TRP123 4.8 30.2 1.0 N A:PRO100 4.8 30.1 1.0 CG A:TYR126 4.9 39.7 1.0 O A:TRP123 4.9 43.4 1.0 CB A:PRO100 5.0 38.3 1.0 O A:HOH457 5.0 54.6 1.0 C A:GLY127 5.0 48.3 1.0

Chlorine binding site 2 out of 3 in the Nonstructural Protein 10 (NSP10) From Sars Cov-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Nonstructural Protein 10 (NSP10) From Sars Cov-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl205 b:37.4 occ:1.00 O A:HOH455 4.5 44.3 1.0 O A:HOH386 5.0 37.1 1.0

Chlorine binding site 3 out of 3 in the Nonstructural Protein 10 (NSP10) From Sars Cov-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Nonstructural Protein 10 (NSP10) From Sars Cov-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl206 b:37.6 occ:1.00 O A:HOH409 3.0 39.7 1.0 OG1 A:THR12 3.1 32.3 1.0 O A:HOH423 3.2 47.6 1.0 N A:THR12 3.5 25.9 1.0 CA A:GLY9 3.6 30.1 1.0 C A:GLY9 3.7 27.3 1.0 N A:SER11 3.9 27.4 1.0 CB A:THR12 3.9 27.5 1.0 O A:GLY9 3.9 27.8 1.0 CB A:SER11 4.1 25.6 1.0 N A:GLY9 4.1 31.7 1.0 N A:ASN10 4.2 27.1 1.0 CA A:SER11 4.3 24.8 1.0 CA A:THR12 4.3 24.5 1.0 C A:SER11 4.3 27.7 1.0 C A:ASN10 4.7 26.6 1.0 OG A:SER11 4.9 30.7 1.0

A.Rogstam, M.Nyblom, S.Christensen, C.Sele, V.O.Talibov, T.Lindvall, A.A.Rasmussen, I.Andre, Z.Fisher, W.Knecht, F.Kozielski. Crystal Structure of Non-Structural Protein 10 From Severe Acute Respiratory Syndrome Coronavirus-2. Int J Mol Sci V. 21 2020.
ISSN: ESSN 1422-0067
PubMed: 33036230
DOI: 10.3390/IJMS21197375