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Chlorine in PDB 7aay: Crystal Structure of Mertk Kinase Domain in Complex with MerestinibEnzymatic activity of Crystal Structure of Mertk Kinase Domain in Complex with Merestinib
All present enzymatic activity of Crystal Structure of Mertk Kinase Domain in Complex with Merestinib:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of Mertk Kinase Domain in Complex with Merestinib, PDB code: 7aay
was solved by
M.Schimpl,
A.Pflug,
W.Mccoull,
J.W.M.Nissink,
R.C.Overman,
P.B.Rawlins,
C.Truman,
E.Underwood,
J.Warwicker,
J.Winter-Holt,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7aay:
The structure of Crystal Structure of Mertk Kinase Domain in Complex with Merestinib also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Mertk Kinase Domain in Complex with Merestinib
(pdb code 7aay). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Mertk Kinase Domain in Complex with Merestinib, PDB code: 7aay: Jump to Chlorine binding site number: 1; 2; 3; Chlorine binding site 1 out of 3 in 7aayGo back to Chlorine Binding Sites List in 7aay
Chlorine binding site 1 out
of 3 in the Crystal Structure of Mertk Kinase Domain in Complex with Merestinib
Mono view Stereo pair view
Chlorine binding site 2 out of 3 in 7aayGo back to Chlorine Binding Sites List in 7aay
Chlorine binding site 2 out
of 3 in the Crystal Structure of Mertk Kinase Domain in Complex with Merestinib
Mono view Stereo pair view
Chlorine binding site 3 out of 3 in 7aayGo back to Chlorine Binding Sites List in 7aay
Chlorine binding site 3 out
of 3 in the Crystal Structure of Mertk Kinase Domain in Complex with Merestinib
Mono view Stereo pair view
Reference:
A.Pflug,
M.Schimpl,
J.W.M.Nissink,
R.C.Overman,
P.B.Rawlins,
C.Truman,
E.Underwood,
J.Warwicker,
J.Winter-Holt,
W.Mccoull.
A-Loop Interactions in Mer Tyrosine Kinase Give Rise to Inhibitors with Two-Step Mechanism and Long Residence Time of Binding. Biochem.J. V. 477 4443 2020.
Page generated: Sun Dec 13 10:22:29 2020
ISSN: ESSN 1470-8728 PubMed: 33119085 DOI: 10.1042/BCJ20200735 |
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