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Chlorine in PDB 7aj2: Structure of DYRK1A in Complex with Compound 3Enzymatic activity of Structure of DYRK1A in Complex with Compound 3
All present enzymatic activity of Structure of DYRK1A in Complex with Compound 3:
2.7.12.1; Protein crystallography data
The structure of Structure of DYRK1A in Complex with Compound 3, PDB code: 7aj2
was solved by
P.Dokurno,
A.E.Surgenor,
A.Kotschy,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of DYRK1A in Complex with Compound 3
(pdb code 7aj2). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of DYRK1A in Complex with Compound 3, PDB code: 7aj2: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 7aj2Go back to Chlorine Binding Sites List in 7aj2
Chlorine binding site 1 out
of 2 in the Structure of DYRK1A in Complex with Compound 3
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 7aj2Go back to Chlorine Binding Sites List in 7aj2
Chlorine binding site 2 out
of 2 in the Structure of DYRK1A in Complex with Compound 3
Mono view Stereo pair view
Reference:
C.Weber,
M.Sipos,
A.Paczal,
B.Balint,
V.Kun,
N.Foloppe,
P.Dokurno,
A.J.Massey,
D.L.Walmsley,
R.E.Hubbard,
J.Murray,
K.Benwell,
T.Edmonds,
D.Demarles,
A.Bruno,
M.Burbridge,
F.Cruzalegui,
A.Kotschy.
Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J.Med.Chem. 2021.
Page generated: Sat Jul 10 12:31:27 2021
ISSN: ISSN 0022-2623 PubMed: 33975430 DOI: 10.1021/ACS.JMEDCHEM.1C00023 |
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