Chlorine in PDB 7av0: LTA4 Hydrolase in Complex with Compound R(13)

Enzymatic activity of LTA4 Hydrolase in Complex with Compound R(13)

All present enzymatic activity of LTA4 Hydrolase in Complex with Compound R(13):
3.3.2.6;

Protein crystallography data

The structure of LTA4 Hydrolase in Complex with Compound R(13), PDB code: 7av0 was solved by H.Srinivas, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.82 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.151, 87.057, 99.611, 90, 90, 90
R / Rfree (%) 15.5 / 19.4

Other elements in 7av0:

The structure of LTA4 Hydrolase in Complex with Compound R(13) also contains other interesting chemical elements:

Ytterbium (Yb) 3 atoms
Zinc (Zn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the LTA4 Hydrolase in Complex with Compound R(13) (pdb code 7av0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the LTA4 Hydrolase in Complex with Compound R(13), PDB code: 7av0:

Chlorine binding site 1 out of 1 in 7av0

Go back to Chlorine Binding Sites List in 7av0
Chlorine binding site 1 out of 1 in the LTA4 Hydrolase in Complex with Compound R(13)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of LTA4 Hydrolase in Complex with Compound R(13) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl708

b:25.1
occ:1.00
CL1 A:RZB708 0.0 25.1 1.0
C2 A:RZB708 1.7 19.9 1.0
C3 A:RZB708 2.7 19.1 1.0
C1 A:RZB708 2.7 20.2 1.0
O A:HOH1058 3.3 23.5 1.0
CG2 A:VAL367 3.6 18.4 1.0
O A:HOH1095 3.8 22.2 1.0
O A:HOH829 3.9 20.1 1.0
C4 A:RZB708 4.0 18.3 1.0
CG A:PRO382 4.0 19.9 1.0
C6 A:RZB708 4.0 18.6 1.0
CD2 A:PHE314 4.1 18.9 1.0
O A:HOH947 4.2 15.6 1.0
CG1 A:VAL367 4.2 19.2 1.0
CB A:PHE314 4.2 14.4 1.0
CB A:PRO382 4.3 15.8 1.0
O A:TRP311 4.4 19.2 1.0
CD A:PRO382 4.5 16.2 1.0
CB A:VAL367 4.5 19.8 1.0
C5 A:RZB708 4.5 18.4 1.0
CG A:PHE314 4.6 15.8 1.0

Reference:

C.Markert, G.Thoma, H.Srinivas, B.Bollbuck, R.M.Luond, W.Miltz, R.Wal̈Chli, R.Wolf, J.Hinrichs, C.Bergsdorf, K.Azzaoui, C.A.Penno, K.Klein, N.Wack, P.Jag̈Er, F.Hasler, C.Beerli, P.Loetscher, J.Dawson, G.Wieczorek, S.Numao, A.Littlewood-Evans, T.A.Rohn. Discovery of LYS006, A Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase. J.Med.Chem. 2021.
ISSN: ISSN 0022-2623
Page generated: Wed Mar 3 12:57:16 2021

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy