Chlorine in PDB 7b05: TRPC4 in Complex with Inhibitor Gfb-8749

Other elements in 7b05:

The structure of TRPC4 in Complex with Inhibitor Gfb-8749 also contains other interesting chemical elements:

Fluorine (F) 8 atoms
Calcium (Ca) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the TRPC4 in Complex with Inhibitor Gfb-8749 (pdb code 7b05). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the TRPC4 in Complex with Inhibitor Gfb-8749, PDB code: 7b05:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 7b05

Go back to Chlorine Binding Sites List in 7b05
Chlorine binding site 1 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1001

b:79.3
occ:1.00
CL A:SJQ1001 0.0 79.3 1.0
CAT A:SJQ1001 1.8 79.3 1.0
CAP A:SJQ1001 2.8 79.3 1.0
CAV A:SJQ1001 2.8 79.3 1.0
OH A:TYR373 2.9 66.7 1.0
N A:SJQ1001 3.0 79.3 1.0
OAW A:SJQ1001 3.0 79.3 1.0
CE1 A:TYR373 3.3 66.7 1.0
CAK A:SJQ1001 3.3 79.3 1.0
CZ A:TYR373 3.3 66.7 1.0
CA A:SJQ1001 3.4 79.3 1.0
NAJ A:SJQ1001 3.4 79.3 1.0
C A:SJQ1001 3.5 79.3 1.0
CAL A:SJQ1001 3.6 79.3 1.0
CD A:ARG491 4.0 62.4 1.0
NAS A:SJQ1001 4.1 79.3 1.0
CAQ A:SJQ1001 4.1 79.3 1.0
O A:SJQ1001 4.2 79.3 1.0
CE1 A:PHE413 4.2 82.1 1.0
CE A:MET441 4.2 73.6 1.0
CD1 A:TYR373 4.3 66.7 1.0
CE2 A:TYR373 4.3 66.7 1.0
CAI A:SJQ1001 4.3 79.3 1.0
O A:SER488 4.4 54.1 1.0
CB A:ARG491 4.5 62.4 1.0
NAR A:SJQ1001 4.6 79.3 1.0
OG A:SER488 4.6 54.1 1.0
CD1 A:PHE413 4.6 82.1 1.0
CZ A:PHE413 4.7 82.1 1.0
CG A:ARG491 4.9 62.4 1.0

Chlorine binding site 2 out of 4 in 7b05

Go back to Chlorine Binding Sites List in 7b05
Chlorine binding site 2 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1001

b:79.2
occ:1.00
CL B:SJQ1001 0.0 79.2 1.0
CAT B:SJQ1001 1.8 79.2 1.0
CAP B:SJQ1001 2.8 79.2 1.0
CAV B:SJQ1001 2.8 79.2 1.0
OH B:TYR373 2.9 66.9 1.0
N B:SJQ1001 3.0 79.2 1.0
OAW B:SJQ1001 3.0 79.2 1.0
CE1 B:TYR373 3.3 66.9 1.0
CAK B:SJQ1001 3.3 79.2 1.0
CZ B:TYR373 3.3 66.9 1.0
CA B:SJQ1001 3.4 79.2 1.0
NAJ B:SJQ1001 3.4 79.2 1.0
C B:SJQ1001 3.5 79.2 1.0
CAL B:SJQ1001 3.6 79.2 1.0
CD B:ARG491 4.0 62.2 1.0
NAS B:SJQ1001 4.1 79.2 1.0
CAQ B:SJQ1001 4.1 79.2 1.0
O B:SJQ1001 4.2 79.2 1.0
CE1 B:PHE413 4.2 82.4 1.0
CE B:MET441 4.2 73.4 1.0
CD1 B:TYR373 4.3 66.9 1.0
CE2 B:TYR373 4.3 66.9 1.0
CAI B:SJQ1001 4.3 79.2 1.0
O B:SER488 4.4 53.7 1.0
CB B:ARG491 4.5 62.2 1.0
NAR B:SJQ1001 4.6 79.2 1.0
OG B:SER488 4.6 53.7 1.0
CD1 B:PHE413 4.6 82.4 1.0
CZ B:PHE413 4.7 82.4 1.0
CG B:ARG491 4.9 62.2 1.0

Chlorine binding site 3 out of 4 in 7b05

Go back to Chlorine Binding Sites List in 7b05
Chlorine binding site 3 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1001

b:78.7
occ:1.00
CL C:SJQ1001 0.0 78.7 1.0
CAT C:SJQ1001 1.8 78.7 1.0
CAP C:SJQ1001 2.8 78.7 1.0
CAV C:SJQ1001 2.8 78.7 1.0
OH C:TYR373 2.9 66.4 1.0
N C:SJQ1001 3.0 78.7 1.0
OAW C:SJQ1001 3.0 78.7 1.0
CE1 C:TYR373 3.3 66.4 1.0
CAK C:SJQ1001 3.3 78.7 1.0
CZ C:TYR373 3.3 66.4 1.0
CA C:SJQ1001 3.4 78.7 1.0
NAJ C:SJQ1001 3.4 78.7 1.0
C C:SJQ1001 3.5 78.7 1.0
CAL C:SJQ1001 3.6 78.7 1.0
CD C:ARG491 4.0 61.7 1.0
NAS C:SJQ1001 4.1 78.7 1.0
CAQ C:SJQ1001 4.1 78.7 1.0
O C:SJQ1001 4.2 78.7 1.0
CE1 C:PHE413 4.2 81.8 1.0
CE C:MET441 4.2 73.2 1.0
CD1 C:TYR373 4.3 66.4 1.0
CE2 C:TYR373 4.3 66.4 1.0
CAI C:SJQ1001 4.3 78.7 1.0
O C:SER488 4.4 53.4 1.0
CB C:ARG491 4.5 61.7 1.0
NAR C:SJQ1001 4.6 78.7 1.0
OG C:SER488 4.6 53.4 1.0
CD1 C:PHE413 4.6 81.8 1.0
CZ C:PHE413 4.7 81.8 1.0
CG C:ARG491 4.9 61.7 1.0

Chlorine binding site 4 out of 4 in 7b05

Go back to Chlorine Binding Sites List in 7b05
Chlorine binding site 4 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1001

b:78.8
occ:1.00
CL D:SJQ1001 0.0 78.8 1.0
CAT D:SJQ1001 1.8 78.8 1.0
CAP D:SJQ1001 2.8 78.8 1.0
CAV D:SJQ1001 2.8 78.8 1.0
OH D:TYR373 2.9 66.0 1.0
N D:SJQ1001 3.0 78.8 1.0
OAW D:SJQ1001 3.0 78.8 1.0
CE1 D:TYR373 3.3 66.0 1.0
CAK D:SJQ1001 3.3 78.8 1.0
CZ D:TYR373 3.3 66.0 1.0
CA D:SJQ1001 3.4 78.8 1.0
NAJ D:SJQ1001 3.4 78.8 1.0
C D:SJQ1001 3.5 78.8 1.0
CAL D:SJQ1001 3.6 78.8 1.0
CD D:ARG491 4.0 61.9 1.0
NAS D:SJQ1001 4.1 78.8 1.0
CAQ D:SJQ1001 4.1 78.8 1.0
O D:SJQ1001 4.2 78.8 1.0
CE1 D:PHE413 4.2 81.6 1.0
CE D:MET441 4.2 73.2 1.0
CD1 D:TYR373 4.3 66.0 1.0
CE2 D:TYR373 4.3 66.0 1.0
CAI D:SJQ1001 4.3 78.8 1.0
O D:SER488 4.4 53.2 1.0
CB D:ARG491 4.5 61.9 1.0
NAR D:SJQ1001 4.6 78.8 1.0
OG D:SER488 4.6 53.2 1.0
CD1 D:PHE413 4.6 81.6 1.0
CZ D:PHE413 4.7 81.6 1.0
CG D:ARG491 4.9 61.9 1.0

Reference:

D.Vinayagam, D.Quentin, J.Yu-Strzelczyk, O.Sitsel, F.Merino, M.Stabrin, O.Hofnagel, M.Yu, M.W.Ledeboer, G.Nagel, G.Malojcic, S.Raunser. Structural Basis of TRPC4 Regulation By Calmodulin and Pharmacological Agents. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33236980
DOI: 10.7554/ELIFE.60603
Page generated: Sun Dec 13 10:24:00 2020

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