Chlorine in PDB 7b05: TRPC4 in Complex with Inhibitor Gfb-8749

The structure of TRPC4 in Complex with Inhibitor Gfb-8749 also contains other interesting chemical elements:

Fluorine	(F)	8 atoms
Calcium	(Ca)	4 atoms

The binding sites of Chlorine atom in the TRPC4 in Complex with Inhibitor Gfb-8749 (pdb code 7b05). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the TRPC4 in Complex with Inhibitor Gfb-8749, PDB code: 7b05:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1001 b:79.3 occ:1.00 CL A:SJQ1001 0.0 79.3 1.0 CAT A:SJQ1001 1.8 79.3 1.0 CAP A:SJQ1001 2.8 79.3 1.0 CAV A:SJQ1001 2.8 79.3 1.0 OH A:TYR373 2.9 66.7 1.0 N A:SJQ1001 3.0 79.3 1.0 OAW A:SJQ1001 3.0 79.3 1.0 CE1 A:TYR373 3.3 66.7 1.0 CAK A:SJQ1001 3.3 79.3 1.0 CZ A:TYR373 3.3 66.7 1.0 CA A:SJQ1001 3.4 79.3 1.0 NAJ A:SJQ1001 3.4 79.3 1.0 C A:SJQ1001 3.5 79.3 1.0 CAL A:SJQ1001 3.6 79.3 1.0 CD A:ARG491 4.0 62.4 1.0 NAS A:SJQ1001 4.1 79.3 1.0 CAQ A:SJQ1001 4.1 79.3 1.0 O A:SJQ1001 4.2 79.3 1.0 CE1 A:PHE413 4.2 82.1 1.0 CE A:MET441 4.2 73.6 1.0 CD1 A:TYR373 4.3 66.7 1.0 CE2 A:TYR373 4.3 66.7 1.0 CAI A:SJQ1001 4.3 79.3 1.0 O A:SER488 4.4 54.1 1.0 CB A:ARG491 4.5 62.4 1.0 NAR A:SJQ1001 4.6 79.3 1.0 OG A:SER488 4.6 54.1 1.0 CD1 A:PHE413 4.6 82.1 1.0 CZ A:PHE413 4.7 82.1 1.0 CG A:ARG491 4.9 62.4 1.0

Chlorine binding site 2 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1001 b:79.2 occ:1.00 CL B:SJQ1001 0.0 79.2 1.0 CAT B:SJQ1001 1.8 79.2 1.0 CAP B:SJQ1001 2.8 79.2 1.0 CAV B:SJQ1001 2.8 79.2 1.0 OH B:TYR373 2.9 66.9 1.0 N B:SJQ1001 3.0 79.2 1.0 OAW B:SJQ1001 3.0 79.2 1.0 CE1 B:TYR373 3.3 66.9 1.0 CAK B:SJQ1001 3.3 79.2 1.0 CZ B:TYR373 3.3 66.9 1.0 CA B:SJQ1001 3.4 79.2 1.0 NAJ B:SJQ1001 3.4 79.2 1.0 C B:SJQ1001 3.5 79.2 1.0 CAL B:SJQ1001 3.6 79.2 1.0 CD B:ARG491 4.0 62.2 1.0 NAS B:SJQ1001 4.1 79.2 1.0 CAQ B:SJQ1001 4.1 79.2 1.0 O B:SJQ1001 4.2 79.2 1.0 CE1 B:PHE413 4.2 82.4 1.0 CE B:MET441 4.2 73.4 1.0 CD1 B:TYR373 4.3 66.9 1.0 CE2 B:TYR373 4.3 66.9 1.0 CAI B:SJQ1001 4.3 79.2 1.0 O B:SER488 4.4 53.7 1.0 CB B:ARG491 4.5 62.2 1.0 NAR B:SJQ1001 4.6 79.2 1.0 OG B:SER488 4.6 53.7 1.0 CD1 B:PHE413 4.6 82.4 1.0 CZ B:PHE413 4.7 82.4 1.0 CG B:ARG491 4.9 62.2 1.0

Chlorine binding site 3 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1001 b:78.7 occ:1.00 CL C:SJQ1001 0.0 78.7 1.0 CAT C:SJQ1001 1.8 78.7 1.0 CAP C:SJQ1001 2.8 78.7 1.0 CAV C:SJQ1001 2.8 78.7 1.0 OH C:TYR373 2.9 66.4 1.0 N C:SJQ1001 3.0 78.7 1.0 OAW C:SJQ1001 3.0 78.7 1.0 CE1 C:TYR373 3.3 66.4 1.0 CAK C:SJQ1001 3.3 78.7 1.0 CZ C:TYR373 3.3 66.4 1.0 CA C:SJQ1001 3.4 78.7 1.0 NAJ C:SJQ1001 3.4 78.7 1.0 C C:SJQ1001 3.5 78.7 1.0 CAL C:SJQ1001 3.6 78.7 1.0 CD C:ARG491 4.0 61.7 1.0 NAS C:SJQ1001 4.1 78.7 1.0 CAQ C:SJQ1001 4.1 78.7 1.0 O C:SJQ1001 4.2 78.7 1.0 CE1 C:PHE413 4.2 81.8 1.0 CE C:MET441 4.2 73.2 1.0 CD1 C:TYR373 4.3 66.4 1.0 CE2 C:TYR373 4.3 66.4 1.0 CAI C:SJQ1001 4.3 78.7 1.0 O C:SER488 4.4 53.4 1.0 CB C:ARG491 4.5 61.7 1.0 NAR C:SJQ1001 4.6 78.7 1.0 OG C:SER488 4.6 53.4 1.0 CD1 C:PHE413 4.6 81.8 1.0 CZ C:PHE413 4.7 81.8 1.0 CG C:ARG491 4.9 61.7 1.0

Chlorine binding site 4 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8749


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of TRPC4 in Complex with Inhibitor Gfb-8749 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1001 b:78.8 occ:1.00 CL D:SJQ1001 0.0 78.8 1.0 CAT D:SJQ1001 1.8 78.8 1.0 CAP D:SJQ1001 2.8 78.8 1.0 CAV D:SJQ1001 2.8 78.8 1.0 OH D:TYR373 2.9 66.0 1.0 N D:SJQ1001 3.0 78.8 1.0 OAW D:SJQ1001 3.0 78.8 1.0 CE1 D:TYR373 3.3 66.0 1.0 CAK D:SJQ1001 3.3 78.8 1.0 CZ D:TYR373 3.3 66.0 1.0 CA D:SJQ1001 3.4 78.8 1.0 NAJ D:SJQ1001 3.4 78.8 1.0 C D:SJQ1001 3.5 78.8 1.0 CAL D:SJQ1001 3.6 78.8 1.0 CD D:ARG491 4.0 61.9 1.0 NAS D:SJQ1001 4.1 78.8 1.0 CAQ D:SJQ1001 4.1 78.8 1.0 O D:SJQ1001 4.2 78.8 1.0 CE1 D:PHE413 4.2 81.6 1.0 CE D:MET441 4.2 73.2 1.0 CD1 D:TYR373 4.3 66.0 1.0 CE2 D:TYR373 4.3 66.0 1.0 CAI D:SJQ1001 4.3 78.8 1.0 O D:SER488 4.4 53.2 1.0 CB D:ARG491 4.5 61.9 1.0 NAR D:SJQ1001 4.6 78.8 1.0 OG D:SER488 4.6 53.2 1.0 CD1 D:PHE413 4.6 81.6 1.0 CZ D:PHE413 4.7 81.6 1.0 CG D:ARG491 4.9 61.9 1.0

D.Vinayagam, D.Quentin, J.Yu-Strzelczyk, O.Sitsel, F.Merino, M.Stabrin, O.Hofnagel, M.Yu, M.W.Ledeboer, G.Nagel, G.Malojcic, S.Raunser. Structural Basis of TRPC4 Regulation By Calmodulin and Pharmacological Agents. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33236980
DOI: 10.7554/ELIFE.60603