Chlorine in PDB 7b0s: TRPC4 in Complex with Inhibitor Gfb-8438

The structure of TRPC4 in Complex with Inhibitor Gfb-8438 also contains other interesting chemical elements:

Fluorine	(F)	12 atoms
Calcium	(Ca)	4 atoms

The binding sites of Chlorine atom in the TRPC4 in Complex with Inhibitor Gfb-8438 (pdb code 7b0s). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the TRPC4 in Complex with Inhibitor Gfb-8438, PDB code: 7b0s:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1001 b:70.1 occ:1.00 CL1 A:S9Q1001 0.0 70.1 1.0 C4 A:S9Q1001 1.8 70.1 1.0 OH A:TYR373 2.7 49.0 1.0 C3 A:S9Q1001 2.8 70.1 1.0 C5 A:S9Q1001 2.8 70.1 1.0 O2 A:S9Q1001 3.0 70.1 1.0 N1 A:S9Q1001 3.1 70.1 1.0 CE1 A:TYR373 3.3 49.0 1.0 CZ A:TYR373 3.4 49.0 1.0 OG A:SER488 3.5 42.7 1.0 C7 A:S9Q1001 3.5 70.1 1.0 C2 A:S9Q1001 3.8 70.1 1.0 CB A:SER488 4.0 42.7 1.0 CG A:ARG491 4.0 51.4 1.0 CE A:MET441 4.1 63.9 1.0 CA A:SER488 4.1 42.7 1.0 C6 A:S9Q1001 4.2 70.1 1.0 N2 A:S9Q1001 4.2 70.1 1.0 CB A:ARG491 4.2 51.4 1.0 C8 A:S9Q1001 4.3 70.1 1.0 SD A:MET441 4.3 63.9 1.0 O A:SER488 4.5 42.7 1.0 CD1 A:TYR373 4.6 49.0 1.0 CE2 A:TYR373 4.7 49.0 1.0 N3 A:S9Q1001 4.7 70.1 1.0 C A:SER488 4.8 42.7 1.0

Chlorine binding site 2 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1001 b:70.5 occ:1.00 CL1 B:S9Q1001 0.0 70.5 1.0 C4 B:S9Q1001 1.8 70.5 1.0 OH B:TYR373 2.7 48.7 1.0 C3 B:S9Q1001 2.8 70.5 1.0 C5 B:S9Q1001 2.8 70.5 1.0 O2 B:S9Q1001 3.0 70.5 1.0 N1 B:S9Q1001 3.1 70.5 1.0 CE1 B:TYR373 3.3 48.7 1.0 CZ B:TYR373 3.4 48.7 1.0 OG B:SER488 3.5 42.4 1.0 C7 B:S9Q1001 3.5 70.5 1.0 C2 B:S9Q1001 3.8 70.5 1.0 CB B:SER488 4.0 42.4 1.0 CG B:ARG491 4.0 51.4 1.0 CE B:MET441 4.1 64.3 1.0 CA B:SER488 4.1 42.4 1.0 C6 B:S9Q1001 4.2 70.5 1.0 N2 B:S9Q1001 4.2 70.5 1.0 CB B:ARG491 4.2 51.4 1.0 C8 B:S9Q1001 4.3 70.5 1.0 SD B:MET441 4.3 64.3 1.0 O B:SER488 4.5 42.4 1.0 CD1 B:TYR373 4.6 48.7 1.0 CE2 B:TYR373 4.7 48.7 1.0 N3 B:S9Q1001 4.7 70.5 1.0 C B:SER488 4.8 42.4 1.0

Chlorine binding site 3 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1001 b:70.4 occ:1.00 CL1 C:S9Q1001 0.0 70.4 1.0 C4 C:S9Q1001 1.8 70.4 1.0 OH C:TYR373 2.7 48.5 1.0 C3 C:S9Q1001 2.8 70.4 1.0 C5 C:S9Q1001 2.8 70.4 1.0 O2 C:S9Q1001 3.0 70.4 1.0 N1 C:S9Q1001 3.1 70.4 1.0 CE1 C:TYR373 3.3 48.5 1.0 CZ C:TYR373 3.4 48.5 1.0 OG C:SER488 3.5 42.3 1.0 C7 C:S9Q1001 3.5 70.4 1.0 C2 C:S9Q1001 3.8 70.4 1.0 CB C:SER488 4.0 42.3 1.0 CG C:ARG491 4.0 51.5 1.0 CE C:MET441 4.1 64.1 1.0 CA C:SER488 4.1 42.3 1.0 C6 C:S9Q1001 4.2 70.4 1.0 N2 C:S9Q1001 4.2 70.4 1.0 CB C:ARG491 4.2 51.5 1.0 C8 C:S9Q1001 4.3 70.4 1.0 SD C:MET441 4.3 64.1 1.0 O C:SER488 4.5 42.3 1.0 CD1 C:TYR373 4.6 48.5 1.0 CE2 C:TYR373 4.7 48.5 1.0 N3 C:S9Q1001 4.7 70.4 1.0 C C:SER488 4.8 42.3 1.0

Chlorine binding site 4 out of 4 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1001 b:70.2 occ:1.00 CL1 D:S9Q1001 0.0 70.2 1.0 C4 D:S9Q1001 1.8 70.2 1.0 OH D:TYR373 2.7 48.7 1.0 C3 D:S9Q1001 2.8 70.2 1.0 C5 D:S9Q1001 2.8 70.2 1.0 O2 D:S9Q1001 3.0 70.2 1.0 N1 D:S9Q1001 3.1 70.2 1.0 CE1 D:TYR373 3.3 48.7 1.0 CZ D:TYR373 3.4 48.7 1.0 OG D:SER488 3.5 42.5 1.0 C7 D:S9Q1001 3.5 70.2 1.0 C2 D:S9Q1001 3.8 70.2 1.0 CB D:SER488 4.0 42.5 1.0 CG D:ARG491 4.0 51.2 1.0 CE D:MET441 4.1 63.9 1.0 CA D:SER488 4.1 42.5 1.0 C6 D:S9Q1001 4.2 70.2 1.0 N2 D:S9Q1001 4.2 70.2 1.0 CB D:ARG491 4.2 51.2 1.0 C8 D:S9Q1001 4.3 70.2 1.0 SD D:MET441 4.3 63.9 1.0 O D:SER488 4.5 42.5 1.0 CD1 D:TYR373 4.6 48.7 1.0 CE2 D:TYR373 4.7 48.7 1.0 N3 D:S9Q1001 4.7 70.2 1.0 C D:SER488 4.8 42.5 1.0

D.Vinayagam, D.Quentin, J.Yu-Strzelczyk, O.Sitsel, F.Merino, M.Stabrin, O.Hofnagel, M.Yu, M.W.Ledeboer, G.Nagel, G.Malojcic, S.Raunser. Structural Basis of TRPC4 Regulation By Calmodulin and Pharmacological Agents. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33236980
DOI: 10.7554/ELIFE.60603