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Chlorine in PDB 7bdp: 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1017

Enzymatic activity of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1017

All present enzymatic activity of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1017:
5.2.1.8;

Protein crystallography data

The structure of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1017, PDB code: 7bdp was solved by M.Wolter, L.V.Dijck, P.J.Cossar, C.Ottmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.63 / 1.75
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 81.989, 111.691, 62.463, 90, 90, 90
R / Rfree (%) 17.3 / 21.7

Other elements in 7bdp:

The structure of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1017 also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1017 (pdb code 7bdp). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1017, PDB code: 7bdp:

Chlorine binding site 1 out of 1 in 7bdp

Go back to Chlorine Binding Sites List in 7bdp
Chlorine binding site 1 out of 1 in the 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1017


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of 14-3-3 Sigma with PIN1 Binding Site PS72 and Covalently Bound LVD1017 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl301

b:17.1
occ:1.00
 CL1 A:TJB301 0.0 17.1 1.0
C18 A:TJB301 1.8 15.4 1.0
C02 A:TJB301 2.7 16.8 1.0
C17 A:TJB301 2.8 22.4 1.0
C01 A:TJB301 2.9 16.4 1.0
CZ3 P:TRP73 3.4 29.4 1.0
CE2 A:PHE119 3.5 7.8 1.0
OG A:SER45 3.5 14.3 1.0
O A:HOH429 3.7 19.9 1.0
CZ A:PHE119 3.7 8.1 1.0
O A:HOH448 3.7 25.1 1.0
OD1 A:ASN42 3.7 12.2 0.5
CH2 P:TRP73 3.8 42.0 1.0
CE3 P:TRP73 3.8 21.4 1.0
OD1 A:ASN42 3.9 13.1 0.5
C03 A:TJB301 4.0 11.6 1.0
C05 A:TJB301 4.0 23.4 1.0
O A:HOH571 4.1 11.0 1.0
CB A:SER45 4.1 8.5 1.0
NZ A:LYS122 4.3 12.8 1.0
CD1 A:ILE168 4.5 18.5 1.0
C04 A:TJB301 4.6 17.6 1.0
CZ2 P:TRP73 4.6 31.6 1.0
CD2 A:PHE119 4.6 7.5 1.0
CD2 P:TRP73 4.6 30.0 1.0
CE1 A:PHE119 4.8 5.5 1.0
CG A:ASN42 4.9 11.6 0.5
CE2 P:TRP73 4.9 33.7 1.0

Reference:

P.J.Cossar, M.Wolter, L.Van Dijck, D.Valenti, L.M.Levy, C.Ottmann, L.Brunsveld. Reversible Covalent Imine-Tethering For Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc. 2021.
ISSN: ESSN 1520-5126
PubMed: 34047554
DOI: 10.1021/JACS.1C03035
Page generated: Mon Jul 29 19:05:28 2024

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