Chlorine in PDB 7bhw: Crystal Structure of MAT2A Bound to Allosteric Inhibitor (Compound 29)

Enzymatic activity of Crystal Structure of MAT2A Bound to Allosteric Inhibitor (Compound 29)

All present enzymatic activity of Crystal Structure of MAT2A Bound to Allosteric Inhibitor (Compound 29):
2.5.1.6;

Protein crystallography data

The structure of Crystal Structure of MAT2A Bound to Allosteric Inhibitor (Compound 29), PDB code: 7bhw was solved by M.Schimpl, C.De Fusco, U.Borjesson, T.Cheung, I.Collie, L.Evans, P.Narasimhan, C.Stubbs, M.Vazquez-Chantada, D.J.Wagner, M.Grondine, S.Tentarelli, E.Underwood, A.Argyrou, S.Bagal, E.Chiarparin, G.Robb, J.S.Scott, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 16.38 / 1.15
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 68.58, 94.199, 117.404, 90, 90, 90
R / Rfree (%) 15.5 / 16.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of MAT2A Bound to Allosteric Inhibitor (Compound 29) (pdb code 7bhw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of MAT2A Bound to Allosteric Inhibitor (Compound 29), PDB code: 7bhw:

Chlorine binding site 1 out of 1 in 7bhw

Go back to Chlorine Binding Sites List in 7bhw
Chlorine binding site 1 out of 1 in the Crystal Structure of MAT2A Bound to Allosteric Inhibitor (Compound 29)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of MAT2A Bound to Allosteric Inhibitor (Compound 29) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl401

b:12.3
occ:1.00
CL A:TNW401 0.0 12.3 1.0
C13 A:TNW401 1.7 12.1 1.0
C12 A:TNW401 2.7 11.1 1.0
C14 A:TNW401 2.7 12.1 1.0
C15 A:TNW401 4.0 12.1 1.0
C11 A:TNW401 4.0 10.7 1.0
C16 A:TNW401 4.5 11.0 1.0
CE2 A:PHE20 4.7 11.8 1.0
CD2 A:PHE20 4.9 10.9 1.0

Reference:

C.De Fusco, M.Schimpl, C.De Fusco, U.Borjesson, T.Cheung, I.Collie, L.Evans, P.Narasimhan, C.Stubbs, M.Vazquez-Chantada, D.J.Wagner, M.Grondine, S.Tentarelli, E.Underwood, A.Argyrou, S.Bagal, E.Chiarparin, G.Robb, J.S.Scott. N/A N/A.
ISSN: ISSN 0022-2623
DOI: 10.1021/ACS.JMEDCHEM.1C00067
Page generated: Sat Jul 10 12:33:47 2021

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