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Chlorine in PDB 7biv: Inhibitor of MDM2-P53 InteractionEnzymatic activity of Inhibitor of MDM2-P53 Interaction
All present enzymatic activity of Inhibitor of MDM2-P53 Interaction:
2.3.2.27; Protein crystallography data
The structure of Inhibitor of MDM2-P53 Interaction, PDB code: 7biv
was solved by
P.A.Williams,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7biv:
The structure of Inhibitor of MDM2-P53 Interaction also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Inhibitor of MDM2-P53 Interaction
(pdb code 7biv). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Inhibitor of MDM2-P53 Interaction, PDB code: 7biv: Chlorine binding site 1 out of 1 in 7bivGo back to Chlorine Binding Sites List in 7biv
Chlorine binding site 1 out
of 1 in the Inhibitor of MDM2-P53 Interaction
Mono view Stereo pair view
Reference:
G.Chessari,
I.R.Hardcastle,
J.S.Ahn,
B.Anil,
E.Anscombe,
R.H.Bawn,
L.D.Bevan,
T.J.Blackburn,
I.Buck,
C.Cano,
B.Carbain,
J.Castro,
B.Cons,
S.J.Cully,
J.A.Endicott,
L.Fazal,
B.T.Golding,
R.J.Griffin,
K.Haggerty,
S.J.Harnor,
K.Hearn,
S.Hobson,
R.S.Holvey,
S.Howard,
C.E.Jennings,
C.N.Johnson,
J.Lunec,
D.C.Miller,
D.R.Newell,
M.E.M.Noble,
J.Reeks,
C.H.Revill,
C.Riedinger,
J.D.St Denis,
E.Tamanini,
H.Thomas,
N.T.Thompson,
M.Vinkovic,
S.R.Wedge,
P.A.Williams,
N.E.Wilsher,
B.Zhang,
Y.Zhao.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-P53 Protein-Protein Interaction. J.Med.Chem. 2021.
Page generated: Sat Apr 17 15:12:35 2021
ISSN: ISSN 0022-2623 PubMed: 33761253 DOI: 10.1021/ACS.JMEDCHEM.0C02188 |
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