Chlorine in PDB 7cr4: Human KCNQ2-Cam in Complex with ZTZ240

The structure of Human KCNQ2-Cam in Complex with ZTZ240 also contains other interesting chemical elements:

Fluorine

(F)

4 atoms

The binding sites of Chlorine atom in the Human KCNQ2-Cam in Complex with ZTZ240 (pdb code 7cr4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Human KCNQ2-Cam in Complex with ZTZ240, PDB code: 7cr4:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Human KCNQ2-Cam in Complex with ZTZ240


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human KCNQ2-Cam in Complex with ZTZ240 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1001 b:0.6 occ:1.00 CL1 A:GB91001 0.0 0.6 1.0 C12 A:GB91001 1.8 0.6 1.0 C11 A:GB91001 2.7 0.6 1.0 H8 A:GB91001 2.8 0.6 1.0 N2 A:GB91001 2.8 0.6 1.0 CE2 A:PHE168 3.2 0.2 1.0 CA A:ARG210 3.4 1.0 1.0 CD2 A:PHE168 3.6 0.2 1.0 O A:ASP212 3.9 0.6 1.0 O A:ARG210 3.9 1.0 1.0 O A:ILE209 4.0 0.1 1.0 C9 A:GB91001 4.0 0.6 1.0 C A:ARG210 4.1 1.0 1.0 C6 A:GB91001 4.1 0.6 1.0 N A:ARG210 4.2 1.0 1.0 CB A:ARG210 4.2 1.0 1.0 C A:ILE209 4.4 0.1 1.0 CZ A:PHE168 4.4 0.2 1.0 C2 A:GB91001 4.6 0.6 1.0 CG A:ARG210 4.6 1.0 1.0 H7 A:GB91001 4.8 0.6 1.0 H4 A:GB91001 4.8 0.6 1.0 O A:ARG213 4.8 0.2 1.0 CA A:ARG213 4.8 0.2 1.0 C A:ASP212 4.8 0.6 1.0 CG A:PHE168 4.9 0.2 1.0 CG2 A:ILE209 5.0 0.1 1.0

Chlorine binding site 2 out of 4 in the Human KCNQ2-Cam in Complex with ZTZ240


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human KCNQ2-Cam in Complex with ZTZ240 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1001 b:0.7 occ:1.00 CL1 B:GB91001 0.0 0.7 1.0 C12 B:GB91001 1.8 0.7 1.0 C11 B:GB91001 2.7 0.7 1.0 H8 B:GB91001 2.8 0.7 1.0 N2 B:GB91001 2.8 0.7 1.0 CE2 B:PHE168 3.2 0.0 1.0 CA B:ARG210 3.4 0.5 1.0 CD2 B:PHE168 3.6 0.0 1.0 O B:ASP212 3.9 0.7 1.0 O B:ARG210 3.9 0.5 1.0 O B:ILE209 4.0 0.5 1.0 C9 B:GB91001 4.0 0.7 1.0 C B:ARG210 4.1 0.5 1.0 C6 B:GB91001 4.1 0.7 1.0 N B:ARG210 4.2 0.5 1.0 CB B:ARG210 4.2 0.5 1.0 C B:ILE209 4.4 0.5 1.0 CZ B:PHE168 4.4 0.0 1.0 C2 B:GB91001 4.6 0.7 1.0 CG B:ARG210 4.6 0.5 1.0 H7 B:GB91001 4.7 0.7 1.0 O B:ARG213 4.8 0.9 1.0 H4 B:GB91001 4.8 0.7 1.0 CA B:ARG213 4.8 0.9 1.0 C B:ASP212 4.8 0.7 1.0 CG B:PHE168 4.9 0.0 1.0 CG2 B:ILE209 5.0 0.5 1.0

Chlorine binding site 3 out of 4 in the Human KCNQ2-Cam in Complex with ZTZ240


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Human KCNQ2-Cam in Complex with ZTZ240 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1001 b:0.5 occ:1.00 CL1 D:GB91001 0.0 0.5 1.0 C12 D:GB91001 1.8 0.5 1.0 C11 D:GB91001 2.7 0.5 1.0 H8 D:GB91001 2.8 0.5 1.0 N2 D:GB91001 2.8 0.5 1.0 CE2 D:PHE168 3.2 0.1 1.0 CA D:ARG210 3.4 0.8 1.0 CD2 D:PHE168 3.6 0.1 1.0 O D:ASP212 3.9 0.5 1.0 O D:ARG210 3.9 0.8 1.0 O D:ILE209 4.0 0.6 1.0 C9 D:GB91001 4.0 0.5 1.0 C D:ARG210 4.1 0.8 1.0 C6 D:GB91001 4.1 0.5 1.0 N D:ARG210 4.2 0.8 1.0 CB D:ARG210 4.2 0.8 1.0 C D:ILE209 4.4 0.6 1.0 CZ D:PHE168 4.4 0.1 1.0 C2 D:GB91001 4.6 0.5 1.0 CG D:ARG210 4.6 0.8 1.0 H7 D:GB91001 4.8 0.5 1.0 O D:ARG213 4.8 0.5 1.0 H4 D:GB91001 4.8 0.5 1.0 CA D:ARG213 4.8 0.5 1.0 C D:ASP212 4.8 0.5 1.0 CG D:PHE168 4.9 0.1 1.0 CG2 D:ILE209 5.0 0.6 1.0

Chlorine binding site 4 out of 4 in the Human KCNQ2-Cam in Complex with ZTZ240


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Human KCNQ2-Cam in Complex with ZTZ240 within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl1001 b:0.4 occ:1.00 CL1 F:GB91001 0.0 0.4 1.0 C12 F:GB91001 1.8 0.4 1.0 C11 F:GB91001 2.7 0.4 1.0 H8 F:GB91001 2.8 0.4 1.0 N2 F:GB91001 2.8 0.4 1.0 CE2 F:PHE168 3.2 0.1 1.0 CA F:ARG210 3.4 0.4 1.0 CD2 F:PHE168 3.6 0.1 1.0 O F:ASP212 3.9 0.1 1.0 O F:ARG210 3.9 0.4 1.0 O F:ILE209 4.0 0.8 1.0 C9 F:GB91001 4.0 0.4 1.0 C F:ARG210 4.1 0.4 1.0 C6 F:GB91001 4.1 0.4 1.0 N F:ARG210 4.2 0.4 1.0 CB F:ARG210 4.2 0.4 1.0 C F:ILE209 4.4 0.8 1.0 CZ F:PHE168 4.4 0.1 1.0 C2 F:GB91001 4.6 0.4 1.0 CG F:ARG210 4.6 0.4 1.0 H7 F:GB91001 4.7 0.4 1.0 O F:ARG213 4.8 0.0 1.0 H4 F:GB91001 4.8 0.4 1.0 CA F:ARG213 4.8 0.0 1.0 C F:ASP212 4.8 0.1 1.0 CG F:PHE168 4.9 0.1 1.0 CG2 F:ILE209 5.0 0.8 1.0

X.Li, Q.Zhang, P.Guo, J.Fu, L.Mei, D.Lv, J.Wang, D.Lai, S.Ye, H.Yang, J.Guo. Molecular Basis For Ligand Activation of the Human KCNQ2 Channel. Cell Res. 2020.
ISSN: ISSN 1001-0602
PubMed: 32884139
DOI: 10.1038/S41422-020-00410-8