Chlorine in PDB 7czm: Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex

The structure of Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex, PDB code: 7czm was solved by Z.X.Zhou, L.F.Pan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.96 / 2.00
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	73.978, 70.624, 56.337, 90, 109.27, 90
R / Rfree (%)	20.3 / 22.3

The binding sites of Chlorine atom in the Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex (pdb code 7czm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex, PDB code: 7czm:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1602 b:43.6 occ:1.00 NZ A:LYS1568 2.6 80.3 1.0 CE A:LYS1568 3.5 73.4 1.0 CD1 A:LEU1578 3.6 68.0 1.0 CA A:GLY1579 3.9 48.6 1.0 O A:ALA1567 4.0 51.1 1.0 CD A:LYS1568 4.1 65.3 1.0 N A:GLY1579 4.3 54.6 1.0 NE2 A:GLN1566 4.5 54.5 1.0 CD A:GLN1566 4.5 56.9 1.0 CA A:LYS1568 4.6 53.7 1.0 CG A:GLN1566 4.9 43.9 1.0 OE1 A:GLN1566 4.9 59.4 1.0 CG A:LEU1578 4.9 61.6 1.0 CD2 A:LEU1578 5.0 69.0 1.0 C A:ALA1567 5.0 51.2 1.0

Chlorine binding site 2 out of 4 in the Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1603 b:46.0 occ:0.50 NZ A:LYS1569 3.4 99.9 1.0 N A:GLN1571 3.9 67.3 1.0 N A:ALA1570 4.2 64.2 1.0 CB A:ALA1570 4.2 73.3 1.0 CB A:GLN1571 4.2 82.2 1.0 CA A:ALA1570 4.5 63.3 1.0 CE A:LYS1569 4.6 97.5 1.0 C A:ALA1570 4.6 64.4 1.0 CA A:GLN1571 4.7 63.5 1.0 CB A:LYS1569 4.8 68.4 1.0

Chlorine binding site 3 out of 4 in the Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1702 b:52.0 occ:1.00 CH2 B:TRP1590 3.3 79.6 1.0 NH2 A:ARG1499 3.4 33.1 1.0 CZ2 B:TRP1590 3.4 75.8 1.0 CZ A:ARG1499 3.6 34.6 1.0 N B:GLU1494 3.7 35.5 1.0 NE A:ARG1499 4.0 34.9 1.0 NH1 A:ARG1499 4.1 36.6 1.0 CA B:SER1493 4.1 38.2 1.0 CD1 A:ILE1498 4.3 68.2 1.0 C B:SER1493 4.4 37.0 1.0 CB B:GLU1494 4.5 48.5 1.0 CB B:SER1493 4.6 34.1 1.0 CA B:GLU1494 4.6 38.7 1.0 CZ3 B:TRP1590 4.7 72.6 1.0 O B:HIS1492 4.8 36.6 1.0 OG B:SER1493 4.8 39.0 1.0 CG B:GLU1494 4.8 64.9 1.0 O B:GLU1494 4.8 36.9 1.0 CE2 B:TRP1590 4.8 76.1 1.0 CD A:ARG1499 4.8 38.5 1.0

Chlorine binding site 4 out of 4 in the Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of FIP200 Claw/P-Optineurin Lir Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1703 b:55.0 occ:1.00 NH1 B:ARG1584 3.0 65.7 1.0 NH2 B:ARG1573 3.6 69.2 1.0 CD B:ARG1584 3.6 56.0 1.0 N B:SER1532 3.6 46.9 1.0 OG B:SER1532 3.9 65.8 1.0 CB B:SER1532 4.0 59.1 1.0 CZ B:ARG1584 4.1 66.5 1.0 ND1 B:HIS1531 4.3 58.3 1.0 NE B:ARG1584 4.3 57.5 1.0 CE1 B:HIS1531 4.3 69.0 1.0 CA B:HIS1531 4.3 43.1 1.0 CG B:HIS1531 4.4 52.7 1.0 CZ B:PHE1574 4.4 48.2 1.0 NE2 B:HIS1531 4.4 62.8 1.0 CA B:SER1532 4.5 51.6 1.0 CD2 B:HIS1531 4.5 58.0 1.0 C B:HIS1531 4.5 46.9 1.0 CD B:ARG1573 4.7 51.9 1.0 CZ B:ARG1573 4.8 61.9 1.0 CE1 B:PHE1574 4.8 45.9 1.0 CG B:ARG1584 4.9 57.9 1.0 CB B:HIS1531 5.0 38.1 1.0

Z.Zhou, J.Liu, T.Fu, P.Wu, C.Peng, X.Gong, Y.Wang, M.Zhang, Y.Li, Y.Wang, X.Xu, M.Li, L.Pan. Phosphorylation Regulates the Binding of Autophagy Receptors to FIP200 Claw Domain For Selective Autophagy Initiation. Nat Commun V. 12 1570 2021.
ISSN: ESSN 2041-1723
PubMed: 33692357
DOI: 10.1038/S41467-021-21874-1