Chlorine in PDB 7d99: Human Potassium-Chloride Co-Transporter KCC4

The structure of Human Potassium-Chloride Co-Transporter KCC4 also contains other interesting chemical elements:

Potassium

(K)

2 atoms

The binding sites of Chlorine atom in the Human Potassium-Chloride Co-Transporter KCC4 (pdb code 7d99). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Human Potassium-Chloride Co-Transporter KCC4, PDB code: 7d99:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Human Potassium-Chloride Co-Transporter KCC4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Potassium-Chloride Co-Transporter KCC4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1302 b:14.9 occ:1.00 O A:PRO429 3.1 5.2 1.0 K A:K1301 3.4 5.3 1.0 N A:VAL135 3.4 7.8 1.0 CA A:GLY134 3.6 12.8 1.0 CA A:SER430 3.8 6.6 1.0 OH A:TYR216 3.8 4.4 1.0 C A:GLY134 3.9 12.8 1.0 C A:PRO429 3.9 5.2 1.0 O A:ILE132 4.0 7.0 1.0 N A:ILE136 4.0 6.1 1.0 N A:GLY134 4.0 12.8 1.0 CG1 A:ILE136 4.1 6.1 1.0 N A:SER430 4.2 6.6 1.0 CE1 A:TYR216 4.3 4.4 1.0 CB A:SER430 4.5 6.6 1.0 CG1 A:VAL135 4.5 7.8 1.0 CB A:ILE136 4.5 6.1 1.0 CA A:VAL135 4.5 7.8 1.0 CE A:MET215 4.6 3.9 1.0 CZ A:TYR216 4.6 4.4 1.0 OG A:SER430 4.6 6.6 1.0 C A:SER430 4.7 6.6 1.0 C A:VAL135 4.8 7.8 1.0 CA A:ILE136 4.9 6.1 1.0 O A:SER430 5.0 6.6 1.0 CB A:VAL135 5.0 7.8 1.0 O A:GLY134 5.0 12.8 1.0

Chlorine binding site 2 out of 4 in the Human Potassium-Chloride Co-Transporter KCC4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Potassium-Chloride Co-Transporter KCC4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1303 b:12.4 occ:1.00 OH A:TYR589 2.5 3.2 1.0 N A:GLY433 2.9 18.0 1.0 N A:ILE434 3.4 7.0 1.0 CA A:GLY433 3.5 18.0 1.0 CZ A:TYR589 3.6 3.2 1.0 CE1 A:PHE585 3.7 2.8 1.0 CE1 A:PHE205 3.8 6.6 1.0 CD1 A:PHE585 3.8 2.8 1.0 N A:MET435 3.8 13.1 1.0 C A:GLY433 3.8 18.0 1.0 CG A:MET435 3.9 13.1 1.0 C A:THR432 3.9 5.9 1.0 CE1 A:TYR589 3.9 3.2 1.0 CB A:THR432 4.2 5.9 1.0 CA A:THR432 4.2 5.9 1.0 CB A:MET435 4.2 13.1 1.0 CA A:ILE434 4.4 7.0 1.0 CB A:ILE434 4.5 7.0 1.0 CZ A:PHE205 4.6 6.6 1.0 C A:ILE434 4.6 7.0 1.0 CD1 A:PHE205 4.6 6.6 1.0 CA A:MET435 4.7 13.1 1.0 CZ A:PHE585 4.7 2.8 1.0 CE2 A:TYR589 4.8 3.2 1.0 CG A:PHE585 4.9 2.8 1.0 O A:GLY433 4.9 18.0 1.0 O A:THR432 4.9 5.9 1.0 CG1 A:ILE434 5.0 7.0 1.0

Chlorine binding site 3 out of 4 in the Human Potassium-Chloride Co-Transporter KCC4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Human Potassium-Chloride Co-Transporter KCC4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1302 b:14.9 occ:1.00 O B:PRO429 3.1 5.2 1.0 K B:K1301 3.4 5.3 1.0 N B:VAL135 3.4 7.8 1.0 CA B:GLY134 3.6 12.8 1.0 CA B:SER430 3.8 6.6 1.0 OH B:TYR216 3.8 4.4 1.0 C B:GLY134 3.9 12.8 1.0 C B:PRO429 3.9 5.2 1.0 O B:ILE132 4.0 7.0 1.0 N B:ILE136 4.0 6.1 1.0 N B:GLY134 4.0 12.8 1.0 CG1 B:ILE136 4.1 6.1 1.0 N B:SER430 4.2 6.6 1.0 CE1 B:TYR216 4.3 4.4 1.0 CB B:SER430 4.5 6.6 1.0 CG1 B:VAL135 4.5 7.8 1.0 CB B:ILE136 4.5 6.1 1.0 CA B:VAL135 4.5 7.8 1.0 CE B:MET215 4.6 3.9 1.0 CZ B:TYR216 4.6 4.4 1.0 OG B:SER430 4.6 6.6 1.0 C B:SER430 4.7 6.6 1.0 C B:VAL135 4.8 7.8 1.0 CA B:ILE136 4.9 6.1 1.0 O B:SER430 5.0 6.6 1.0 CB B:VAL135 5.0 7.8 1.0 O B:GLY134 5.0 12.8 1.0

Chlorine binding site 4 out of 4 in the Human Potassium-Chloride Co-Transporter KCC4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Human Potassium-Chloride Co-Transporter KCC4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1303 b:12.4 occ:1.00 OH B:TYR589 2.5 3.2 1.0 N B:GLY433 2.9 18.0 1.0 N B:ILE434 3.4 7.0 1.0 CA B:GLY433 3.5 18.0 1.0 CZ B:TYR589 3.6 3.2 1.0 CE1 B:PHE585 3.7 2.8 1.0 CE1 B:PHE205 3.8 6.6 1.0 CD1 B:PHE585 3.8 2.8 1.0 N B:MET435 3.8 13.1 1.0 C B:GLY433 3.8 18.0 1.0 CG B:MET435 3.9 13.1 1.0 C B:THR432 3.9 5.9 1.0 CE1 B:TYR589 3.9 3.2 1.0 CB B:THR432 4.2 5.9 1.0 CA B:THR432 4.2 5.9 1.0 CB B:MET435 4.2 13.1 1.0 CA B:ILE434 4.4 7.0 1.0 CB B:ILE434 4.5 7.0 1.0 CZ B:PHE205 4.6 6.6 1.0 C B:ILE434 4.6 7.0 1.0 CD1 B:PHE205 4.6 6.6 1.0 CA B:MET435 4.7 13.1 1.0 CZ B:PHE585 4.7 2.8 1.0 CE2 B:TYR589 4.8 3.2 1.0 CG B:PHE585 4.9 2.8 1.0 O B:GLY433 4.9 18.0 1.0 O B:THR432 4.9 5.9 1.0 CG1 B:ILE434 5.0 7.0 1.0

Y.Xie, S.Chang, C.Zhao, F.Wang, S.Liu, J.Wang, E.Delpire, S.Ye, J.Guo. Structures and An Activation Mechanism of Human Potassium-Chloride Cotransporters. Sci Adv V. 6 2020.
ISSN: ESSN 2375-2548
PubMed: 33310850
DOI: 10.1126/SCIADV.ABC5883