Chlorine in PDB 7ekt: Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
(pdb code 7ekt). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 10 binding sites of Chlorine where determined in the
Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596, PDB code: 7ekt:
Jump to Chlorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Chlorine binding site 1 out
of 10 in 7ekt
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Chlorine Binding Sites List in 7ekt
Chlorine binding site 1 out
of 10 in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
 Mono view
 Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl603
b:73.8
occ:1.00
|
CL08
|
A:I33603
|
0.0
|
73.8
|
1.0
|
C07
|
A:I33603
|
1.8
|
73.8
|
1.0
|
C06
|
A:I33603
|
2.7
|
73.8
|
1.0
|
C09
|
A:I33603
|
2.8
|
73.8
|
1.0
|
S12
|
A:I33603
|
3.6
|
73.8
|
1.0
|
CB
|
A:ASP186
|
3.7
|
77.7
|
1.0
|
OG
|
A:SER56
|
3.7
|
68.2
|
1.0
|
OD2
|
A:ASP186
|
3.8
|
77.7
|
1.0
|
C10
|
A:I33603
|
4.1
|
73.8
|
1.0
|
C05
|
A:I33603
|
4.1
|
73.8
|
1.0
|
CG
|
A:ASP186
|
4.2
|
77.7
|
1.0
|
C11
|
A:I33603
|
4.6
|
73.8
|
1.0
|
CB
|
A:SER56
|
4.6
|
68.2
|
1.0
|
O
|
A:LEU57
|
4.7
|
68.2
|
1.0
|
CB
|
E:GLU211
|
4.7
|
88.8
|
1.0
|
CG
|
A:GLN79
|
4.9
|
69.4
|
1.0
|
CA
|
A:ASP186
|
5.0
|
77.7
|
1.0
|
|
Chlorine binding site 2 out
of 10 in 7ekt
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Chlorine Binding Sites List in 7ekt
Chlorine binding site 2 out
of 10 in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
 Mono view
 Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl604
b:95.0
occ:1.00
|
CL1
|
A:I34604
|
0.0
|
95.0
|
1.0
|
C20
|
A:I34604
|
1.8
|
95.0
|
1.0
|
C03
|
A:I34604
|
2.8
|
95.0
|
1.0
|
C19
|
A:I34604
|
2.8
|
95.0
|
1.0
|
O02
|
A:I34604
|
3.0
|
95.0
|
1.0
|
C01
|
A:I34604
|
3.6
|
95.0
|
1.0
|
O
|
A:ASN236
|
3.7
|
87.6
|
1.0
|
CD2
|
A:LEU278
|
3.9
|
96.2
|
1.0
|
C04
|
A:I34604
|
4.0
|
95.0
|
1.0
|
C08
|
A:I34604
|
4.0
|
95.0
|
1.0
|
ND2
|
A:ASN236
|
4.1
|
87.6
|
1.0
|
CB
|
A:ASN236
|
4.3
|
87.6
|
1.0
|
C05
|
A:I34604
|
4.5
|
95.0
|
1.0
|
CB
|
E:ALA280
|
4.6
|
99.1
|
1.0
|
C
|
A:ASN236
|
4.6
|
87.6
|
1.0
|
O
|
E:MET276
|
4.7
|
96.6
|
1.0
|
CB
|
E:MET276
|
4.7
|
96.6
|
1.0
|
CG
|
A:ASN236
|
4.7
|
87.6
|
1.0
|
CA
|
A:ASN236
|
4.8
|
87.6
|
1.0
|
CD2
|
E:LEU277
|
4.9
|
96.4
|
1.0
|
C
|
E:MET276
|
4.9
|
96.6
|
1.0
|
|
Chlorine binding site 3 out
of 10 in 7ekt
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Chlorine Binding Sites List in 7ekt
Chlorine binding site 3 out
of 10 in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
 Mono view
 Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl601
b:73.8
occ:1.00
|
CL08
|
B:I33601
|
0.0
|
73.8
|
1.0
|
C07
|
B:I33601
|
1.8
|
73.8
|
1.0
|
C06
|
B:I33601
|
2.7
|
73.8
|
1.0
|
C09
|
B:I33601
|
2.8
|
73.8
|
1.0
|
S12
|
B:I33601
|
3.6
|
73.8
|
1.0
|
CB
|
B:ASP186
|
3.7
|
77.7
|
1.0
|
OD2
|
B:ASP186
|
3.7
|
77.7
|
1.0
|
OG
|
B:SER56
|
3.8
|
68.2
|
1.0
|
C10
|
B:I33601
|
4.1
|
73.8
|
1.0
|
C05
|
B:I33601
|
4.1
|
73.8
|
1.0
|
CG
|
B:ASP186
|
4.1
|
77.7
|
1.0
|
C11
|
B:I33601
|
4.6
|
73.8
|
1.0
|
CB
|
B:SER56
|
4.7
|
68.2
|
1.0
|
CB
|
A:GLU211
|
4.7
|
88.8
|
1.0
|
O
|
B:LEU57
|
4.8
|
68.2
|
1.0
|
CG
|
B:GLN79
|
5.0
|
69.4
|
1.0
|
CA
|
B:ASP186
|
5.0
|
77.7
|
1.0
|
|
Chlorine binding site 4 out
of 10 in 7ekt
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Chlorine Binding Sites List in 7ekt
Chlorine binding site 4 out
of 10 in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
 Mono view
 Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl602
b:95.0
occ:1.00
|
CL1
|
B:I34602
|
0.0
|
95.0
|
1.0
|
C20
|
B:I34602
|
1.8
|
95.0
|
1.0
|
C03
|
B:I34602
|
2.8
|
95.0
|
1.0
|
C19
|
B:I34602
|
2.8
|
95.0
|
1.0
|
O02
|
B:I34602
|
3.0
|
95.0
|
1.0
|
C01
|
B:I34602
|
3.6
|
95.0
|
1.0
|
O
|
B:ASN236
|
3.7
|
87.6
|
1.0
|
CD2
|
B:LEU278
|
3.9
|
96.2
|
1.0
|
ND2
|
B:ASN236
|
4.0
|
87.6
|
1.0
|
C04
|
B:I34602
|
4.0
|
95.0
|
1.0
|
C08
|
B:I34602
|
4.0
|
95.0
|
1.0
|
CB
|
B:ASN236
|
4.2
|
87.6
|
1.0
|
C05
|
B:I34602
|
4.5
|
95.0
|
1.0
|
C
|
B:ASN236
|
4.6
|
87.6
|
1.0
|
CB
|
A:ALA280
|
4.6
|
99.1
|
1.0
|
CG
|
B:ASN236
|
4.6
|
87.6
|
1.0
|
O
|
A:MET276
|
4.7
|
96.6
|
1.0
|
CB
|
A:MET276
|
4.7
|
96.6
|
1.0
|
CA
|
B:ASN236
|
4.7
|
87.6
|
1.0
|
CD2
|
A:LEU277
|
4.9
|
96.4
|
1.0
|
C
|
A:MET276
|
4.9
|
96.6
|
1.0
|
|
Chlorine binding site 5 out
of 10 in 7ekt
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Chlorine Binding Sites List in 7ekt
Chlorine binding site 5 out
of 10 in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
 Mono view
 Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl601
b:73.8
occ:1.00
|
CL08
|
C:I33601
|
0.0
|
73.8
|
1.0
|
C07
|
C:I33601
|
1.8
|
73.8
|
1.0
|
C06
|
C:I33601
|
2.7
|
73.8
|
1.0
|
C09
|
C:I33601
|
2.8
|
73.8
|
1.0
|
S12
|
C:I33601
|
3.6
|
73.8
|
1.0
|
CB
|
C:ASP186
|
3.7
|
77.7
|
1.0
|
OG
|
C:SER56
|
3.8
|
68.2
|
1.0
|
OD2
|
C:ASP186
|
3.8
|
77.7
|
1.0
|
C10
|
C:I33601
|
4.1
|
73.8
|
1.0
|
C05
|
C:I33601
|
4.1
|
73.8
|
1.0
|
CG
|
C:ASP186
|
4.1
|
77.7
|
1.0
|
C11
|
C:I33601
|
4.6
|
73.8
|
1.0
|
CB
|
C:SER56
|
4.6
|
68.2
|
1.0
|
O
|
C:LEU57
|
4.7
|
68.2
|
1.0
|
CB
|
B:GLU211
|
4.7
|
88.8
|
1.0
|
CA
|
C:ASP186
|
5.0
|
77.7
|
1.0
|
CG
|
C:GLN79
|
5.0
|
69.4
|
1.0
|
|
Chlorine binding site 6 out
of 10 in 7ekt
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Chlorine Binding Sites List in 7ekt
Chlorine binding site 6 out
of 10 in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
 Mono view
 Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl602
b:95.0
occ:1.00
|
CL1
|
C:I34602
|
0.0
|
95.0
|
1.0
|
C20
|
C:I34602
|
1.8
|
95.0
|
1.0
|
C03
|
C:I34602
|
2.8
|
95.0
|
1.0
|
C19
|
C:I34602
|
2.8
|
95.0
|
1.0
|
O02
|
C:I34602
|
3.0
|
95.0
|
1.0
|
C01
|
C:I34602
|
3.6
|
95.0
|
1.0
|
O
|
C:ASN236
|
3.7
|
87.6
|
1.0
|
CD2
|
C:LEU278
|
3.9
|
96.2
|
1.0
|
C04
|
C:I34602
|
4.0
|
95.0
|
1.0
|
C08
|
C:I34602
|
4.0
|
95.0
|
1.0
|
ND2
|
C:ASN236
|
4.1
|
87.6
|
1.0
|
CB
|
C:ASN236
|
4.2
|
87.6
|
1.0
|
C05
|
C:I34602
|
4.5
|
95.0
|
1.0
|
CB
|
B:ALA280
|
4.6
|
99.1
|
1.0
|
C
|
C:ASN236
|
4.6
|
87.6
|
1.0
|
O
|
B:MET276
|
4.7
|
96.6
|
1.0
|
CB
|
B:MET276
|
4.7
|
96.6
|
1.0
|
CG
|
C:ASN236
|
4.7
|
87.6
|
1.0
|
CA
|
C:ASN236
|
4.8
|
87.6
|
1.0
|
CD2
|
B:LEU277
|
4.9
|
96.4
|
1.0
|
C
|
B:MET276
|
4.9
|
96.6
|
1.0
|
|
Chlorine binding site 7 out
of 10 in 7ekt
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Chlorine Binding Sites List in 7ekt
Chlorine binding site 7 out
of 10 in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
 Mono view
 Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl601
b:73.8
occ:1.00
|
CL08
|
D:I33601
|
0.0
|
73.8
|
1.0
|
C07
|
D:I33601
|
1.8
|
73.8
|
1.0
|
C06
|
D:I33601
|
2.7
|
73.8
|
1.0
|
C09
|
D:I33601
|
2.8
|
73.8
|
1.0
|
S12
|
D:I33601
|
3.6
|
73.8
|
1.0
|
CB
|
D:ASP186
|
3.6
|
77.7
|
1.0
|
OD2
|
D:ASP186
|
3.7
|
77.7
|
1.0
|
OG
|
D:SER56
|
3.8
|
68.2
|
1.0
|
C10
|
D:I33601
|
4.1
|
73.8
|
1.0
|
C05
|
D:I33601
|
4.1
|
73.8
|
1.0
|
CG
|
D:ASP186
|
4.1
|
77.7
|
1.0
|
C11
|
D:I33601
|
4.6
|
73.8
|
1.0
|
CB
|
D:SER56
|
4.7
|
68.2
|
1.0
|
O
|
D:LEU57
|
4.7
|
68.2
|
1.0
|
CB
|
C:GLU211
|
4.7
|
88.8
|
1.0
|
CA
|
D:ASP186
|
4.9
|
77.7
|
1.0
|
CG
|
D:GLN79
|
5.0
|
69.4
|
1.0
|
|
Chlorine binding site 8 out
of 10 in 7ekt
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Chlorine Binding Sites List in 7ekt
Chlorine binding site 8 out
of 10 in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
 Mono view
 Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl602
b:95.0
occ:1.00
|
CL1
|
D:I34602
|
0.0
|
95.0
|
1.0
|
C20
|
D:I34602
|
1.8
|
95.0
|
1.0
|
C03
|
D:I34602
|
2.8
|
95.0
|
1.0
|
C19
|
D:I34602
|
2.8
|
95.0
|
1.0
|
O02
|
D:I34602
|
3.0
|
95.0
|
1.0
|
C01
|
D:I34602
|
3.6
|
95.0
|
1.0
|
O
|
D:ASN236
|
3.7
|
87.6
|
1.0
|
CD2
|
D:LEU278
|
4.0
|
96.2
|
1.0
|
C04
|
D:I34602
|
4.0
|
95.0
|
1.0
|
C08
|
D:I34602
|
4.0
|
95.0
|
1.0
|
ND2
|
D:ASN236
|
4.1
|
87.6
|
1.0
|
CB
|
D:ASN236
|
4.2
|
87.6
|
1.0
|
C05
|
D:I34602
|
4.5
|
95.0
|
1.0
|
C
|
D:ASN236
|
4.6
|
87.6
|
1.0
|
CB
|
C:ALA280
|
4.6
|
99.1
|
1.0
|
CG
|
D:ASN236
|
4.6
|
87.6
|
1.0
|
O
|
C:MET276
|
4.7
|
96.6
|
1.0
|
CB
|
C:MET276
|
4.7
|
96.6
|
1.0
|
CA
|
D:ASN236
|
4.7
|
87.6
|
1.0
|
CD2
|
C:LEU277
|
4.9
|
96.4
|
1.0
|
C
|
C:MET276
|
4.9
|
96.6
|
1.0
|
|
Chlorine binding site 9 out
of 10 in 7ekt
Go back to
Chlorine Binding Sites List in 7ekt
Chlorine binding site 9 out
of 10 in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
 Mono view
 Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 9 of Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Cl601
b:73.8
occ:1.00
|
CL08
|
E:I33601
|
0.0
|
73.8
|
1.0
|
C07
|
E:I33601
|
1.8
|
73.8
|
1.0
|
C06
|
E:I33601
|
2.7
|
73.8
|
1.0
|
C09
|
E:I33601
|
2.8
|
73.8
|
1.0
|
S12
|
E:I33601
|
3.6
|
73.8
|
1.0
|
CB
|
E:ASP186
|
3.7
|
77.7
|
1.0
|
OG
|
E:SER56
|
3.7
|
68.2
|
1.0
|
OD2
|
E:ASP186
|
3.8
|
77.7
|
1.0
|
C10
|
E:I33601
|
4.1
|
73.8
|
1.0
|
C05
|
E:I33601
|
4.1
|
73.8
|
1.0
|
CG
|
E:ASP186
|
4.2
|
77.7
|
1.0
|
C11
|
E:I33601
|
4.6
|
73.8
|
1.0
|
CB
|
E:SER56
|
4.6
|
68.2
|
1.0
|
O
|
E:LEU57
|
4.7
|
68.2
|
1.0
|
CB
|
D:GLU211
|
4.7
|
88.8
|
1.0
|
CA
|
E:ASP186
|
5.0
|
77.7
|
1.0
|
CG
|
E:GLN79
|
5.0
|
69.4
|
1.0
|
|
Chlorine binding site 10 out
of 10 in 7ekt
Go back to
Chlorine Binding Sites List in 7ekt
Chlorine binding site 10 out
of 10 in the Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596
 Mono view
 Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 10 of Human Alpha 7 Nicotinic Acetylcholine Receptor Bound to Evp-6124 and Pnu-120596 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Cl602
b:95.0
occ:1.00
|
CL1
|
E:I34602
|
0.0
|
95.0
|
1.0
|
C20
|
E:I34602
|
1.8
|
95.0
|
1.0
|
C19
|
E:I34602
|
2.8
|
95.0
|
1.0
|
C03
|
E:I34602
|
2.8
|
95.0
|
1.0
|
O02
|
E:I34602
|
3.0
|
95.0
|
1.0
|
C01
|
E:I34602
|
3.6
|
95.0
|
1.0
|
O
|
E:ASN236
|
3.7
|
87.6
|
1.0
|
CD2
|
E:LEU278
|
3.9
|
96.2
|
1.0
|
C04
|
E:I34602
|
4.0
|
95.0
|
1.0
|
C08
|
E:I34602
|
4.0
|
95.0
|
1.0
|
ND2
|
E:ASN236
|
4.1
|
87.6
|
1.0
|
CB
|
E:ASN236
|
4.2
|
87.6
|
1.0
|
C05
|
E:I34602
|
4.5
|
95.0
|
1.0
|
C
|
E:ASN236
|
4.6
|
87.6
|
1.0
|
CB
|
D:ALA280
|
4.6
|
99.1
|
1.0
|
O
|
D:MET276
|
4.7
|
96.6
|
1.0
|
CG
|
E:ASN236
|
4.7
|
87.6
|
1.0
|
CB
|
D:MET276
|
4.7
|
96.6
|
1.0
|
CA
|
E:ASN236
|
4.8
|
87.6
|
1.0
|
CD2
|
D:LEU277
|
4.9
|
96.4
|
1.0
|
C
|
D:MET276
|
4.9
|
96.6
|
1.0
|
|
Reference:
Y.Zhao,
S.Liu,
Y.Zhou,
M.Zhang,
H.Chen,
H.Eric Xu,
D.Sun,
L.Liu,
C.Tian.
Structural Basis of Human Alpha 7 Nicotinic Acetylcholine Receptor Activation. Cell Res. 2021.
ISSN: ISSN 1001-0602
PubMed: 33958730
DOI: 10.1038/S41422-021-00509-6
Page generated: Mon Jul 29 20:31:31 2024
|