Chlorine in PDB 7f9r: Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor L95, L-Proline and Febrifugine

The structure of Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor L95, L-Proline and Febrifugine, PDB code: 7f9r was solved by Y.Manickam, N.Malhotra, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.72 / 1.83
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	114.83, 73.83, 74.7, 90, 111.49, 90
R / Rfree (%)	16.6 / 19.3

The binding sites of Chlorine atom in the Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor L95, L-Proline and Febrifugine (pdb code 7f9r). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor L95, L-Proline and Febrifugine, PDB code: 7f9r:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor L95, L-Proline and Febrifugine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor L95, L-Proline and Febrifugine within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl903 b:87.0 occ:1.00 NH2 A:ARG654 2.8 90.6 1.0 CZ A:ARG654 3.9 89.8 1.0 NE A:ARG658 4.0 50.3 1.0 CZ2 A:TRP670 4.0 43.8 1.0 OD1 A:ASP656 4.1 45.0 1.0 NE A:ARG654 4.2 85.1 1.0 CG A:ASP656 4.2 45.2 1.0 CZ A:ARG658 4.2 56.7 1.0 NH2 A:ARG658 4.3 53.3 1.0 O A:ILE655 4.4 44.5 1.0 CA A:ASP656 4.4 38.6 1.0 CH2 A:TRP670 4.4 44.5 1.0 CB A:ASP656 4.5 40.7 1.0 CD A:ARG658 4.6 50.4 1.0 OD2 A:ASP656 4.6 41.2 1.0 CG A:ARG658 4.9 49.3 1.0 NH1 A:ARG658 4.9 60.2 1.0

Chlorine binding site 2 out of 2 in the Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor L95, L-Proline and Febrifugine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor L95, L-Proline and Febrifugine within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl904 b:101.8 occ:1.00 O A:HOH1144 3.7 77.5 1.0 CD1 A:PHE802 4.4 58.1 1.0 CE1 A:PHE802 4.4 55.3 1.0 CG A:PHE802 4.4 51.2 1.0 CZ A:PHE802 4.4 52.2 1.0 CD2 A:PHE802 4.4 50.4 1.0 CE2 A:PHE802 4.5 50.0 1.0 CZ2 A:TRP501 4.5 54.9 1.0 CD1 A:LEU505 4.6 44.3 1.0 CD2 A:LEU505 4.9 48.8 1.0

N.Malhotra, Y.Manickam, A.Sharma. Tgprs with Double Inhibitors To Be Published.