Chlorine in PDB 7k98: Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams)

Enzymatic activity of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams)

All present enzymatic activity of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams):
6.1.1.20;

Protein crystallography data

The structure of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams), PDB code: 7k98 was solved by K.Michalska, C.Chang, R.Jedrzejczak, J.Wower, B.Baragana, B.Forte, I.H.Gilbert, A.Joachimiak, Center For Structural Genomics Ofinfectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.85 / 2.19
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 147.423, 65.302, 193.481, 90, 109.29, 90
R / Rfree (%) 17.8 / 22.4

Other elements in 7k98:

The structure of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams) also contains other interesting chemical elements:

Magnesium (Mg) 13 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams) (pdb code 7k98). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams), PDB code: 7k98:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 7k98

Go back to Chlorine Binding Sites List in 7k98
Chlorine binding site 1 out of 2 in the Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl902

b:57.2
occ:1.00
 O B:HOH1192 3.0 58.2 1.0
N B:GLY786 3.2 58.5 1.0
NE B:ARG789 3.4 55.6 1.0
CG1 B:VAL749 3.8 42.2 1.0
CD B:ARG789 3.8 40.6 1.0
CA B:GLY786 4.0 57.9 1.0
CA B:ILE785 4.0 51.8 1.0
CG2 B:ILE785 4.1 48.6 1.0
C B:ILE785 4.1 55.0 1.0
CB B:ARG789 4.4 39.0 1.0
CZ B:ARG789 4.5 56.6 1.0
O B:GLN784 4.5 57.0 1.0
NH2 B:ARG789 4.7 57.9 1.0
CB B:ILE785 4.7 50.5 1.0
CG B:ARG789 4.7 46.4 1.0
CB B:VAL749 4.9 42.6 1.0
C B:GLY786 5.0 60.9 1.0

Chlorine binding site 2 out of 2 in 7k98

Go back to Chlorine Binding Sites List in 7k98
Chlorine binding site 2 out of 2 in the Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams) within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl901

b:51.7
occ:1.00
 N E:GLY786 2.9 49.2 1.0
O E:HOH1152 3.0 48.5 1.0
NE E:ARG789 3.2 47.8 1.0
CA E:GLY786 3.6 45.0 1.0
CD E:ARG789 3.7 42.9 1.0
C E:ILE785 3.9 51.8 1.0
CG1 E:VAL749 4.0 47.8 1.0
CA E:ILE785 4.0 52.8 1.0
CG2 E:ILE785 4.2 45.4 1.0
CZ E:ARG789 4.3 53.7 1.0
CB E:ARG789 4.4 36.4 1.0
NH1 E:ARG789 4.6 53.0 1.0
CG E:ARG789 4.6 45.3 1.0
O E:GLN784 4.7 60.0 1.0
CB E:ILE785 4.7 48.6 1.0
C E:GLY786 4.7 52.2 1.0
CD1 E:ILE785 4.8 43.0 1.0
O E:GLY786 5.0 53.0 1.0
CB E:VAL749 5.0 46.1 1.0

Reference:

K.Michalska, R.Jedrzejczak, J.Wower, C.Chang, B.Baragana, I.H.Gilbert, B.Forte, A.Joachimiak. Mycobacterium Tuberculosis Phe-Trna Synthetase: Structural Insights Into Trna Recognition and Aminoacylation. Nucleic Acids Res. 2021.
ISSN: ESSN 1362-4962
PubMed: 33885823
DOI: 10.1093/NAR/GKAB272
Page generated: Sat Jul 10 12:49:14 2021

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