Chlorine in PDB 7k98: Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams)

Enzymatic activity of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams)

All present enzymatic activity of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams):
6.1.1.20;

Protein crystallography data

The structure of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams), PDB code: 7k98 was solved by K.Michalska, C.Chang, R.Jedrzejczak, J.Wower, B.Baragana, B.Forte, I.H.Gilbert, A.Joachimiak, Center For Structural Genomics Ofinfectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	29.85 / 2.19
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	147.423, 65.302, 193.481, 90, 109.29, 90
*R / R_free (%)*	17.8 / 22.4

Other elements in 7k98:

The structure of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams) also contains other interesting chemical elements:

Magnesium

(Mg)

13 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams) (pdb code 7k98). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams), PDB code: 7k98:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 7k98

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Chlorine Binding Sites List in 7k98

Chlorine binding site 1 out of 2 in the Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams)

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Cl902 b:57.2 occ:1.00	O	B:HOH1192	3.0	58.2	1.0
	N	B:GLY786	3.2	58.5	1.0
	NE	B:ARG789	3.4	55.6	1.0
	CG1	B:VAL749	3.8	42.2	1.0
	CD	B:ARG789	3.8	40.6	1.0
	CA	B:GLY786	4.0	57.9	1.0
	CA	B:ILE785	4.0	51.8	1.0
	CG2	B:ILE785	4.1	48.6	1.0
	C	B:ILE785	4.1	55.0	1.0
	CB	B:ARG789	4.4	39.0	1.0
	CZ	B:ARG789	4.5	56.6	1.0
	O	B:GLN784	4.5	57.0	1.0
	NH2	B:ARG789	4.7	57.9	1.0
	CB	B:ILE785	4.7	50.5	1.0
	CG	B:ARG789	4.7	46.4	1.0
	CB	B:VAL749	4.9	42.6	1.0
	C	B:GLY786	5.0	60.9	1.0

Chlorine binding site 2 out of 2 in 7k98

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Chlorine Binding Sites List in 7k98

Chlorine binding site 2 out of 2 in the Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams)

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Preaminoacylation Complex of M. Tuberculosis Phers with Cognate Precursor Trna and 5'-O-(N-Phenylalanyl)Sulfamoyl-Adenosine (F-Ams) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
E:Cl901 b:51.7 occ:1.00	N	E:GLY786	2.9	49.2	1.0
	O	E:HOH1152	3.0	48.5	1.0
	NE	E:ARG789	3.2	47.8	1.0
	CA	E:GLY786	3.6	45.0	1.0
	CD	E:ARG789	3.7	42.9	1.0
	C	E:ILE785	3.9	51.8	1.0
	CG1	E:VAL749	4.0	47.8	1.0
	CA	E:ILE785	4.0	52.8	1.0
	CG2	E:ILE785	4.2	45.4	1.0
	CZ	E:ARG789	4.3	53.7	1.0
	CB	E:ARG789	4.4	36.4	1.0
	NH1	E:ARG789	4.6	53.0	1.0
	CG	E:ARG789	4.6	45.3	1.0
	O	E:GLN784	4.7	60.0	1.0
	CB	E:ILE785	4.7	48.6	1.0
	C	E:GLY786	4.7	52.2	1.0
	CD1	E:ILE785	4.8	43.0	1.0
	O	E:GLY786	5.0	53.0	1.0
	CB	E:VAL749	5.0	46.1	1.0

Reference:

K.Michalska, R.Jedrzejczak, J.Wower, C.Chang, B.Baragana, I.H.Gilbert, B.Forte, A.Joachimiak. Mycobacterium Tuberculosis Phe-Trna Synthetase: Structural Insights Into Trna Recognition and Aminoacylation. Nucleic Acids Res. 2021.
ISSN: ESSN 1362-4962
PubMed: 33885823
DOI: 10.1093/NAR/GKAB272

Page generated: Sun Jul 13 03:12:09 2025

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