Chlorine in PDB 7ku7: Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc.

The structure of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc. also contains other interesting chemical elements:

Fluorine	(F)	2 atoms
Magnesium	(Mg)	4 atoms
Zinc	(Zn)	2 atoms

The binding sites of Chlorine atom in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc. (pdb code 7ku7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc., PDB code: 7ku7:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc. within 5.0Å range: probe atom residue distance (Å) B Occ J:Cl401 b:147.9 occ:1.00 CLAI J:ZZX401 0.0 147.9 1.0 CAV J:ZZX401 1.7 147.9 1.0 CAT J:ZZX401 2.7 147.9 1.0 CAL J:ZZX401 2.7 147.9 1.0 N2 I:DG4 2.7 144.1 1.0 FAH J:ZZX401 2.9 147.9 1.0 O A:SER150 3.1 145.0 1.0 C2 I:DG4 3.3 144.1 1.0 CB A:GLU157 3.4 148.2 1.0 CG A:GLU157 3.6 148.2 1.0 N1 I:DG4 3.9 144.1 1.0 CAJ J:ZZX401 4.0 147.9 1.0 CAU J:ZZX401 4.0 147.9 1.0 N3 I:DG4 4.0 144.1 1.0 CA A:GLN151 4.1 146.8 1.0 N3 J:DC35 4.1 146.2 1.0 C A:SER150 4.2 145.0 1.0 CA A:ALA154 4.2 145.6 1.0 C2 J:DC35 4.3 146.2 1.0 C4 J:DC35 4.5 146.2 1.0 CG A:GLN151 4.5 146.8 1.0 CAK J:ZZX401 4.5 147.9 1.0 O2 J:DC35 4.5 146.2 1.0 CD A:GLU157 4.5 148.2 1.0 CB A:ALA154 4.6 145.6 1.0 N A:GLN151 4.7 146.8 1.0 N1 J:DC35 4.7 146.2 1.0 CB A:GLN151 4.8 146.8 1.0 CA A:GLU157 4.9 148.2 1.0 OE1 A:GLU157 4.9 148.2 1.0 C5 J:DC35 4.9 146.2 1.0 O A:ALA154 4.9 145.6 1.0 N4 J:DC35 4.9 146.2 1.0 N A:ALA154 5.0 145.6 1.0 O A:GLN151 5.0 146.8 1.0 C4 I:DG4 5.0 144.1 1.0 C6 J:DC35 5.0 146.2 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc. within 5.0Å range: probe atom residue distance (Å) B Occ L:Cl401 b:138.8 occ:1.00 CLAI L:ZZX401 0.0 138.8 1.0 CAV L:ZZX401 1.7 138.8 1.0 CAT L:ZZX401 2.7 138.8 1.0 CAL L:ZZX401 2.7 138.8 1.0 N2 K:DG4 2.9 141.6 1.0 FAH L:ZZX401 2.9 138.8 1.0 O E:SER150 3.2 138.5 1.0 CB E:GLU157 3.4 141.3 1.0 C2 K:DG4 3.6 141.6 1.0 CG E:GLU157 3.7 141.3 1.0 CAJ L:ZZX401 4.0 138.8 1.0 CAU L:ZZX401 4.0 138.8 1.0 CA E:GLN151 4.1 134.5 1.0 CA E:ALA154 4.2 138.1 1.0 N3 K:DG4 4.2 141.6 1.0 N1 K:DG4 4.2 141.6 1.0 C E:SER150 4.3 138.5 1.0 C2 L:DC35 4.3 145.2 1.0 N3 L:DC35 4.3 145.2 1.0 CAK L:ZZX401 4.5 138.8 1.0 CB E:ALA154 4.5 138.1 1.0 C4 L:DC35 4.6 145.2 1.0 N1 L:DC35 4.6 145.2 1.0 CD E:GLU157 4.6 141.3 1.0 O2 L:DC35 4.7 145.2 1.0 N E:GLN151 4.7 134.5 1.0 O E:ALA154 4.7 138.1 1.0 CG E:GLN151 4.8 134.5 1.0 C6 L:DC35 4.8 145.2 1.0 CB E:GLN151 4.8 134.5 1.0 C5 L:DC35 4.8 145.2 1.0 CA E:GLU157 4.8 141.3 1.0 O E:GLN151 5.0 134.5 1.0 C E:ALA154 5.0 138.1 1.0 C E:GLN151 5.0 134.5 1.0 OE1 E:GLU157 5.0 141.3 1.0

K.K.Pandey, S.Bera, K.Shi, H.Aihara, D.P.Grandgenett, M.J.Rau, A.V.Oleru, J.A.J.Fitzpatrick, A.N.Engelman. Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 Commun Biol 2021.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-021-01855-2