Chlorine in PDB 7lut: The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution

Enzymatic activity of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution

All present enzymatic activity of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution:
4.2.1.20;

Protein crystallography data

The structure of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution, PDB code: 7lut was solved by E.Hilario, M.F.Dunn, L.J.Mueller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 32.28 / 1.60
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 182.412, 61.086, 67.063, 90, 94.86, 90
R / Rfree (%) 18.7 / 21.7

Other elements in 7lut:

The structure of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution also contains other interesting chemical elements:

Caesium (Cs) 7 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution (pdb code 7lut). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution, PDB code: 7lut:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in 7lut

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Chlorine binding site 1 out of 5 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl305

b:41.6
occ:1.00
 CD1 A:ILE153 3.7 16.4 1.0
O A:HOH416 3.8 22.9 1.0
CB A:ALA59 4.2 23.4 1.0
CD2 A:LEU100 4.4 18.0 1.0
O A:HOH660 4.4 22.8 1.0
O A:ALA59 4.6 23.7 1.0
O A:HOH489 4.8 23.4 1.0
CB A:ALA129 4.9 13.8 1.0
OH A:TYR175 5.0 19.5 1.0
CG1 A:ILE153 5.0 15.0 1.0

Chlorine binding site 2 out of 5 in 7lut

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Chlorine binding site 2 out of 5 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl416

b:62.8
occ:1.00
 OG B:SER143 3.9 27.7 0.5
O B:SER143 4.0 25.4 0.5
O B:SER143 4.1 25.0 0.5
N B:PRO144 4.1 25.1 1.0
CA B:PRO144 4.1 24.5 1.0
C B:SER143 4.1 25.2 0.5
C B:SER143 4.2 24.9 0.5
CB B:SER143 4.4 25.6 0.5
CB B:SER143 4.4 26.6 0.5
CB B:PHE147 4.5 24.3 1.0
CG B:PRO144 4.6 25.2 1.0
CD B:PRO144 4.7 25.1 1.0
CB B:PRO144 4.8 25.1 1.0
CA B:SER143 4.9 25.1 0.5
CA B:SER143 5.0 25.6 0.5
CG B:PHE147 5.0 26.2 1.0

Chlorine binding site 3 out of 5 in 7lut

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Chlorine binding site 3 out of 5 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl417

b:60.3
occ:1.00
 C1 B:DMS405 3.6 54.9 1.0
O B:GLN36 3.7 17.1 1.0
O B:HOH584 3.7 35.0 1.0
O B:LYS37 3.8 17.3 1.0
C B:LYS37 3.8 17.5 1.0
O B:HOH891 4.0 25.4 1.0
CA B:LYS37 4.0 17.8 1.0
N B:ASP38 4.4 15.5 1.0
CD B:PRO39 4.5 18.1 1.0
N B:PRO39 4.5 17.1 1.0
C B:GLN36 4.6 15.9 1.0
O B:HOH921 4.7 46.0 1.0
C B:ASP38 4.8 16.6 1.0
CA B:PRO39 4.8 17.2 1.0
N B:LYS37 4.8 16.2 1.0
S B:DMS405 4.8 59.6 1.0
CG B:GLN42 4.9 13.2 1.0

Chlorine binding site 4 out of 5 in 7lut

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Chlorine binding site 4 out of 5 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl418

b:21.3
occ:1.00
 O B:ASP225 2.9 10.0 1.0
O B:SER249 3.0 16.2 1.0
O B:HOH553 3.3 22.4 1.0
O B:HOH939 3.8 38.2 1.0
C B:ASP225 3.9 10.2 1.0
N B:GLY251 4.0 10.4 1.0
C B:SER249 4.2 15.1 1.0
O B:HOH871 4.2 36.9 1.0
O B:HOH812 4.2 29.6 1.0
CA B:ASP225 4.2 11.0 1.0
O B:HOH892 4.3 19.2 1.0
CB B:ASP225 4.4 11.8 1.0
CA B:GLY251 4.5 10.3 1.0
O B:HOH671 4.6 30.3 1.0
O B:HOH896 4.6 22.6 1.0
C B:VAL250 4.7 11.1 1.0
CA B:VAL250 4.9 11.7 1.0
OD1 B:ASP225 4.9 13.6 1.0

Chlorine binding site 5 out of 5 in 7lut

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Chlorine binding site 5 out of 5 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl419

b:51.3
occ:1.00
 O B:ASP218 3.2 15.8 1.0
OD1 B:ASP218 3.4 23.0 1.0
O B:HOH604 3.6 46.0 1.0
C B:ASP218 4.2 15.6 1.0
CG B:ASP218 4.3 20.8 1.0
CA B:ASP218 4.4 16.0 1.0
CB B:ASP218 4.9 18.0 1.0

Reference:

E.Hilario, M.F.Dunn, L.J.Mueller. The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta-Site at 1.60 Angstrom Resolution. To Be Published.
Page generated: Tue Jul 30 00:13:03 2024

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