Chlorine in PDB 7oxl: Crystal Structure of Human Spermine Oxidase

All present enzymatic activity of Crystal Structure of Human Spermine Oxidase:
1.5.3.16;

The structure of Crystal Structure of Human Spermine Oxidase, PDB code: 7oxl was solved by A.Impagliazzo, S.Johannsson, M.Thomsen, S.Krapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	165.34 / 2.40
Space group	P 3 2 1
Cell size a, b, c (Å), α, β, γ (°)	190.919, 190.919, 43.574, 90, 90, 120
R / Rfree (%)	18.5 / 21.4

The binding sites of Chlorine atom in the Crystal Structure of Human Spermine Oxidase (pdb code 7oxl). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Spermine Oxidase, PDB code: 7oxl:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Human Spermine Oxidase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Spermine Oxidase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:92.1 occ:1.00 NH1 A:ARG290 3.5 68.5 1.0 ND1 A:HIS245 3.8 56.8 1.0 CD A:ARG290 4.1 71.7 1.0 CE1 A:HIS245 4.2 56.1 1.0 CB A:ARG290 4.2 55.8 1.0 CG A:ARG290 4.5 63.4 1.0 CZ A:ARG290 4.5 69.9 1.0 NE A:ARG290 4.8 77.3 1.0 CG A:HIS245 5.0 57.7 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Human Spermine Oxidase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Spermine Oxidase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl504 b:114.6 occ:1.00 OG1 A:THR308 4.2 62.8 1.0 O A:ILE306 4.3 60.2 1.0 N A:THR308 4.5 52.6 1.0 CD1 A:LEU378 4.5 69.7 1.0 C A:GLY374 4.6 66.9 1.0 CG A:GLU375 4.7 90.1 1.0 N A:GLU375 4.7 61.4 1.0 CB A:THR308 4.7 57.1 1.0 O A:GLY374 4.9 68.4 1.0 CA A:GLY374 4.9 68.1 1.0

E.Diaz, S.Adhikary, A.W.J.W.Tepper, D.Riley, R.Ortiz-Meoz, D.Krosky, C.Buyck, C.M.Lamenca, J.Llaveria, L.Fang, J.H.Kalin, V.N.A.Klaren, S.Fahmy, P.L.Shaffer, R.Kirkpatrick, R.J.Carbajo, M.Thomsen, A.Impagliazzo. Structure of Human Spermine Oxidase in Complex with A Highly Selective Allosteric Inhibitor. Commun Biol V. 5 787 2022.
ISSN: ESSN 2399-3642
PubMed: 35931745
DOI: 10.1038/S42003-022-03735-9