Chlorine in PDB 7oy0: Structure of Human Spermine Oxidase in Complex with A Highly Selective Allosteric Inhibitor

Enzymatic activity of Structure of Human Spermine Oxidase in Complex with A Highly Selective Allosteric Inhibitor

All present enzymatic activity of Structure of Human Spermine Oxidase in Complex with A Highly Selective Allosteric Inhibitor:
1.5.3.16;

Protein crystallography data

The structure of Structure of Human Spermine Oxidase in Complex with A Highly Selective Allosteric Inhibitor, PDB code: 7oy0 was solved by A.Impagliazzo, M.Thomsen, S.Johannsson, S.Krapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 167.80 / 2.09
Space group P 3 2 1
Cell size a, b, c (Å), α, β, γ (°) 193.755, 193.755, 44.332, 90, 90, 120
R / Rfree (%) 19.5 / 23.9

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of Human Spermine Oxidase in Complex with A Highly Selective Allosteric Inhibitor (pdb code 7oy0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Human Spermine Oxidase in Complex with A Highly Selective Allosteric Inhibitor, PDB code: 7oy0:

Chlorine binding site 1 out of 1 in 7oy0

Go back to Chlorine Binding Sites List in 7oy0
Chlorine binding site 1 out of 1 in the Structure of Human Spermine Oxidase in Complex with A Highly Selective Allosteric Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Spermine Oxidase in Complex with A Highly Selective Allosteric Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl503

b:53.0
occ:1.00
 N A:GLU55 3.8 51.9 1.0
CG A:GLU55 4.2 51.4 1.0
O A:THR53 4.2 57.7 1.0
CA A:PHE54 4.4 54.0 1.0
CB A:GLU55 4.4 52.4 1.0
CG2 A:THR59 4.4 45.7 1.0
NZ A:LYS311 4.4 54.4 1.0
CZ A:PHE313 4.5 52.6 1.0
C A:PHE54 4.6 54.4 1.0
OH A:TYR364 4.6 65.2 1.0
CA A:GLU55 4.7 52.8 1.0
CE1 A:PHE313 4.7 50.7 1.0
CE1 A:TYR364 4.8 61.6 1.0
CZ A:TYR364 5.0 63.8 1.0

Reference:

E.Diaz, S.Adhikary, A.W.J.W.Tepper, D.Riley, R.Ortiz-Meoz, D.Krosky, C.Buyck, C.M.Lamenca, J.Llaveria, L.Fang, J.H.Kalin, V.N.A.Klaren, S.Fahmy, P.L.Shaffer, R.Kirkpatrick, R.J.Carbajo, M.Thomsen, A.Impagliazzo. Structure of Human Spermine Oxidase in Complex with A Highly Selective Allosteric Inhibitor. Commun Biol V. 5 787 2022.
ISSN: ESSN 2399-3642
PubMed: 35931745
DOI: 10.1038/S42003-022-03735-9
Page generated: Tue Apr 4 21:06:07 2023

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